At pH 5, what is the net charge of the pentapeptide Val-Glu-Cys-Ser-Lys? O-1 O 0 O +1 O +2
At pH 5, what is the net charge of the pentapeptide Val-Glu-Cys-Ser-Lys? O-1 O 0 O +1 O +2
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
Q9
Transcribed Image Text:At pH 5, what is the net charge of the pentapeptide Val-Glu-Cys-Ser-Lys?
O-1
0 0
O +1
O +2
Expert Solution
Step 1
The amino acids contain ionizable groups.
The ionic form of theses ionizable groups depends on the pH of the solution.
The amino groups have a positive charge in the pH below its pKa value, and in the pH above its pKa value, it has a net charge of zero.
The carboxyl group carries a net charge of zero in the pH below its pKa value, and at the pH above its pKa value, it carries a negative charge.
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