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At equilibrium, Rage2 in normal humans exhibits 115 times more folded than unfolded forms. Normally, it has an alanine in the hydrophobic core but in zombies this residue is mutated to a serine. In the core, the serine mutant loses one hydrogen bond (AG°h-bond = -1.4kcal/mol). What is AG°folding for the ala ser mutant? What is the net effect of this mutation for protein folding?

At equilibrium, Rage2 in normal humans exhibits 115 times more folded than unfolded forms. Normally, it has an alanine in the hydrophobic core but in zombies this residue is mutated to a serine. In the core, the serine mutant loses one hydrogen bond (AG°h-bond = -1.4kcal/mol). What is AG°folding for the ala ser mutant? What is the net effect of this mutation for protein folding?

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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At equilibrium, Rage2 in normal humans exhibits 115 times more folded than unfolded forms. Normally, it has an alanine in the hydrophobic core but in zombies this residue is mutated to a serine. In the core, the serine mutant loses one hydrogen bond (AG°h-bond = -1.4kcal/mol). What is AG°folding for the ala ser mutant? What is the net effect of this mutation for protein folding?
Transcribed Image Text:At equilibrium, Rage2 in normal humans exhibits 115 times more folded than unfolded forms. Normally, it has an alanine in the hydrophobic core but in zombies this residue is mutated to a serine. In the core, the serine mutant loses one hydrogen bond (AG°h-bond = -1.4kcal/mol). What is AG°folding for the ala ser mutant? What is the net effect of this mutation for protein folding?
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