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Assume the graphs below show the differential effect of nimodipine on 2 different populations of neurons (population A on the left curve and B on the right curve). Which of the following could explain why it takes more nimodipine to block current in the B neurons? 100 0.36 nM 730 nM 50 EH =-15 mV EH =-80 mV 10-10 10-9 10-8 10-7 10-6 10-5 Nitrendipine (M) Ca2+ current (%)

Assume the graphs below show the differential effect of nimodipine on 2 different populations of neurons (population A on the left curve and B on the right curve). Which of the following could explain why it takes more nimodipine to block current in the B neurons? 100 0.36 nM 730 nM 50 EH =-15 mV EH =-80 mV 10-10 10-9 10-8 10-7 10-6 10-5 Nitrendipine (M) Ca2+ current (%)

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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10-10 10-9 10-8 10-7 10-6 10-5 Nitrendipine (M) The external Ca++ concentration is higher outside B neurons The permeability of Ca++ is higher in B neurons The Ca++ channels in B neurons are rarely inactivated The permeability of Ca++ is lower in B neuron C
Transcribed Image Text:10-10 10-9 10-8 10-7 10-6 10-5 Nitrendipine (M) The external Ca++ concentration is higher outside B neurons The permeability of Ca++ is higher in B neurons The Ca++ channels in B neurons are rarely inactivated The permeability of Ca++ is lower in B neuron C
Assume the graphs below show the differential effect of nimodipine on 2 different populations of neurons (population A on the left curve and B on the right curve). Which of the following could explain why it takes more nimodipine to block current in the B neurons? 100 0.36 nM 730 nM 50 EH =-15 mV EH=-80 mV 10-10 10-9 10-8 10-7 10-6 10-5 Nitrendipine (M) Ca2+ current (%)
Transcribed Image Text:Assume the graphs below show the differential effect of nimodipine on 2 different populations of neurons (population A on the left curve and B on the right curve). Which of the following could explain why it takes more nimodipine to block current in the B neurons? 100 0.36 nM 730 nM 50 EH =-15 mV EH=-80 mV 10-10 10-9 10-8 10-7 10-6 10-5 Nitrendipine (M) Ca2+ current (%)
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