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Assessment Criteria 2.2: Describe and explain protein synthesis Answer the following questions: Leigh syndrome is a metabolic disorder that affects the central nervous system. It can be caused by a mutation in the MT-ATP6 gene. Table 1 Amino acid Isoleucine Glutamic Acid Leucine Methionine Valine Arginine Alanine DNA codon ATT, ATC, ATA GAA, GAG CTG, TTA,TTG ATG GTT, GTC, GTA, GTG CGG, AGA GCT, GCC, GCA, GCG a) Give one piece of evidence from table 1 that shows the genetic code is degenerate. Figure 2 shows one of the mutations in the MT-ATP6 gene that can cause Leigh syndrome. CAA CCA ATA GCC CTG GCC GTA Original gene: Mutated gene: Codon position: CAA CCA ATA GCC CGG GCC GTA 152 153 154 155 156 157 158 b) Explain how a gene is transcribed into mRNA. c) Describe the effect that the mutation shown in Figure 2 will have on the mRNA sequence produced from the MT-ATP6 gene. d) Using Table 1 for reference, describe the effect that the mutation shown in Figure 2 will have on the amino acid sequence produced from the MT-ATP6 gene.

Assessment Criteria 2.2: Describe and explain protein synthesis Answer the following questions: Leigh syndrome is a metabolic disorder that affects the central nervous system. It can be caused by a mutation in the MT-ATP6 gene. Table 1 Amino acid Isoleucine Glutamic Acid Leucine Methionine Valine Arginine Alanine DNA codon ATT, ATC, ATA GAA, GAG CTG, TTA,TTG ATG GTT, GTC, GTA, GTG CGG, AGA GCT, GCC, GCA, GCG a) Give one piece of evidence from table 1 that shows the genetic code is degenerate. Figure 2 shows one of the mutations in the MT-ATP6 gene that can cause Leigh syndrome. CAA CCA ATA GCC CTG GCC GTA Original gene: Mutated gene: Codon position: CAA CCA ATA GCC CGG GCC GTA 152 153 154 155 156 157 158 b) Explain how a gene is transcribed into mRNA. c) Describe the effect that the mutation shown in Figure 2 will have on the mRNA sequence produced from the MT-ATP6 gene. d) Using Table 1 for reference, describe the effect that the mutation shown in Figure 2 will have on the amino acid sequence produced from the MT-ATP6 gene.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Assessment Criteria 2.2: Describe and explain protein synthesis Answer the following questions: Leigh syndrome is a metabolic disorder that affects the central nervous system. It can be caused by a mutation in the MT-ATP6 gene. Table 1 Amino acid Isoleucine Glutamic Acid Leucine Methionine Valine Arginine Alanine DNA codon ATT, ATC, ATA GAA, GAG CTG, TTA,TTG ATG GTT, GTC, GTA, GTG CGG, AGA GCT, GCC, GCA, GCG a) Give one piece of evidence from table 1 that shows the genetic code is degenerate. Figure 2 shows one of the mutations in the MT-ATP6 gene that can cause Leigh syndrome. CAA CCA ATA GCC CTG GCC GTA Original gene: Mutated gene: Codon position: CAA CCA ATA GCC CGG GCC GTA 152 153 154 155 156 157 158 b) Explain how a gene is transcribed into mRNA. c) Describe the effect that the mutation shown in Figure 2 will have on the mRNA sequence produced from the MT-ATP6 gene. d) Using Table 1 for reference, describe the effect that the mutation shown in Figure 2 will have on the amino acid sequence produced from the MT-ATP6 gene.
Transcribed Image Text:Assessment Criteria 2.2: Describe and explain protein synthesis Answer the following questions: Leigh syndrome is a metabolic disorder that affects the central nervous system. It can be caused by a mutation in the MT-ATP6 gene. Table 1 Amino acid Isoleucine Glutamic Acid Leucine Methionine Valine Arginine Alanine DNA codon ATT, ATC, ATA GAA, GAG CTG, TTA,TTG ATG GTT, GTC, GTA, GTG CGG, AGA GCT, GCC, GCA, GCG a) Give one piece of evidence from table 1 that shows the genetic code is degenerate. Figure 2 shows one of the mutations in the MT-ATP6 gene that can cause Leigh syndrome. CAA CCA ATA GCC CTG GCC GTA Original gene: Mutated gene: Codon position: CAA CCA ATA GCC CGG GCC GTA 152 153 154 155 156 157 158 b) Explain how a gene is transcribed into mRNA. c) Describe the effect that the mutation shown in Figure 2 will have on the mRNA sequence produced from the MT-ATP6 gene. d) Using Table 1 for reference, describe the effect that the mutation shown in Figure 2 will have on the amino acid sequence produced from the MT-ATP6 gene.
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