As discussed during week 4, the CCR5A32 mutation provides an example of balancing selection because heterozygotes are more resistant to smallpox than CCR5432 homozygotes or wild type homozygotes. CCR5 is a chemokine receptor that plays a role in immune responses against many pathogens. Reflecting this general function, CCR5A32 homozygotes have increased susceptibility to West Nile Virus. CCR5 also functions as a receptor for HIV, and CCR5A32 homozygotes are resistant to AIDS. Which of the following genetic phenomena is illustrated by this information about the CCR5 gene? Choose the one that is most clear-cut, and justify your choice with 1-2 sentences demonstrating an understanding of the phenomenon you chose.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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As discussed during week 4, the CCR5432 mutation provides an example of
balancing selection because heterozygotes are more resistant to smallpox than
CCR5A32 homozygotes or wild type homozygotes. CCR5 is a chemokine
receptor that plays a role in immune responses against many pathogens.
Reflecting this general function, CCR5A32 homozygotes have increased
susceptibility to West Nile Virus. CCR5 also functions as a receptor for HIV, and
CCR5A32 homozygotes are resistant to AIDS. Which of the following genetic
phenomena is illustrated by this information about the CCR5 gene? Choose the
one that is most clear-cut, and justify your choice with 1-2 sentences
demonstrating an understanding of the phenomenon you chose.
1. Complementation
2. Incomplete penetrance
3. Pleiotropy
4. Epistasis
5. Variable expressivity
Transcribed Image Text:As discussed during week 4, the CCR5432 mutation provides an example of balancing selection because heterozygotes are more resistant to smallpox than CCR5A32 homozygotes or wild type homozygotes. CCR5 is a chemokine receptor that plays a role in immune responses against many pathogens. Reflecting this general function, CCR5A32 homozygotes have increased susceptibility to West Nile Virus. CCR5 also functions as a receptor for HIV, and CCR5A32 homozygotes are resistant to AIDS. Which of the following genetic phenomena is illustrated by this information about the CCR5 gene? Choose the one that is most clear-cut, and justify your choice with 1-2 sentences demonstrating an understanding of the phenomenon you chose. 1. Complementation 2. Incomplete penetrance 3. Pleiotropy 4. Epistasis 5. Variable expressivity
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