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- Explain the difference between a proto-oncogene and a tumor suppressor gene.Which of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growth-inhibiting factors to block cell division (c) more than 120 cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genesA gene that codes for a positive cell cycle regulator is called a(n) _______. a. kinase inhibitor b. tumor suppressor gene c. proto-oncogene d. oncogene
- An oncogene is produced from a that has acquired a .a. proto-oncogene, loss-of-function mutationb. proto-oncogene, gain-of-function mutationc. tumor-suppressor gene, loss-of-function mutationd. tumor-suppressor gene, gain-of-function mutationMatch the gene on the left with the gene category on the right. ERBB2 E-cadherin BRCA1 Cdk4 A. oncogene B. proto-oncogene C. low expression in invasive cells D. tumor suppressor geneWhich of the following accurately compares tumor suppressor genes and proto-oncogenes? A. Both tumor suppressor and proto-oncogenes prevent the spread of cancer by targeting and destroying existing cancer cells. B. A person who has both tumor suppressor and proto-oncogenes will always develop cancer. C. Proto-oncogenes code for growth factors, while tumor suppressor genes inhibit cell division of damaged cells. D. When a proto-oncogene mutates, it becomes a tumor suppressor gene.
- Which of the following is NOT a way in which proto-oncogenes can change to become genes that induce cancer? Group of answer choices a. changes in a control element (enhancer) to increase transcription b. gene amplification c. changes in DNA sequence to produce a product that degrades rapidly d. movement of the gene adjacent to a different control element to increase transcription e. changes in DNA sequence to produce a product that isWhich of the following demonstrates the link between oncogenes and cancer? a.Oncogenes do not have mutations that increase the activity or number of molecules that stimulate mitosis. b.Oncogenes produce molecules that inhibit mitosis. c.They are genes that transform tumor cells into normal cells. d.The mutations in oncogenes increase the activity or number of molecules that stimulate mitosis, leading to irregular cell division.Which of the following associated with cancer development would you expect to be tumor promoters and not genotoxic carcinogens (select all that apply)? A. Excessive alcohol consumption that kills liver cells B. Bisphenol A which mimics the activity of estrogen C. Chemical in pesticides that binds and activates a transcription factor that cause activation of NFkB D. Chemical in cigarette smoke that forms adduct with DNA E. A viral infection that causes ulcerative coilitis of GI tract
- Most forms of cancer involvea. the activation of a single oncogene.b. the inactivation of a single tumor-suppressor gene.c. the activation of multiple oncogenes.d. the activation of multiple oncogenes and the inactivation ofmultiple tumor-suppressor genes.What is a primary function of tumor suppressor genes?a. stop all cells from dividingb. stop certain cells from dividingc. help oncogenes produce oncoproteinsd. allow the cell to skip certain phases of the cellcycleMutations in the ras gene family induce normal cells to proceed into the replication cycle. This converts the ras gene from a ________ gene to a ________ gene. a. proto-oncogene; oncogene b. oncogene; proto-oncogene c. mutant; oncogene d. tumor suppressor; proto-oncogene