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Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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$### Understanding pH-Log Solubility Profiles #### Graph Analysis: The graph titled "pH-log solubility" shows the relationship between pH levels (x-axis) ranging from 0 to 14 and the log solubility of a drug (y-axis) ranging from 0 to 5. The curve indicates how solubility changes with pH. - **Interpretation of the Curve**: - The curve starts at a high log solubility of around 5 at pH 0. - As pH increases from 0 to about 6, the solubility decreases sharply. - Beyond pH 6, the curve levels off, indicating little change in solubility at higher pH values. #### Questions and Answers: 15. **What type of drug classification can be assumed for a drug that demonstrates this type of pH-solubility profile?** - a. WA (Weak Acid) - b. WB (Weak Base) - c. NE (Neutral) 16. **What is the approximate pKa of this drug?** - a. 2 - b. 6 - c. 10 - d. 12 17. **What is the log $ S_0 $ for this drug?** - a. 0.7 - b. 1.4 - c. 3.2 - d. 4.3 This information can help in understanding the solubility behavior of drugs in different pH environments, which is crucial for formulation and drug delivery considerations.$

Transcribed Image Text:### Understanding pH-Log Solubility Profiles #### Graph Analysis: The graph titled "pH-log solubility" shows the relationship between pH levels (x-axis) ranging from 0 to 14 and the log solubility of a drug (y-axis) ranging from 0 to 5. The curve indicates how solubility changes with pH. - **Interpretation of the Curve**: - The curve starts at a high log solubility of around 5 at pH 0. - As pH increases from 0 to about 6, the solubility decreases sharply. - Beyond pH 6, the curve levels off, indicating little change in solubility at higher pH values. #### Questions and Answers: 15. **What type of drug classification can be assumed for a drug that demonstrates this type of pH-solubility profile?** - a. WA (Weak Acid) - b. WB (Weak Base) - c. NE (Neutral) 16. **What is the approximate pKa of this drug?** - a. 2 - b. 6 - c. 10 - d. 12 17. **What is the log $ S_0 $ for this drug?** - a. 0.7 - b. 1.4 - c. 3.2 - d. 4.3 This information can help in understanding the solubility behavior of drugs in different pH environments, which is crucial for formulation and drug delivery considerations.

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