Angiotensin Converting Enzyme (ACE) is the target of ACE inhibitors such as captopril that are used therapeutically to control blood pressure. The enzyme ACE converts angiotensin I to angiotensin II. Angiotensin II is an octapeptide with the sequence Asp-Arg-Val-Tyr-lle-His-Pro-Phe. What will its net charge be at pH 7? OA) -2 OB) -1 Oco OD) + OE) +2

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Angiotensin Converting Enzyme (ACE) is the target of ACE inhibitors such as
captopril that are used therapeutically to control blood pressure. The enzyme
ACE converts angiotensin I to angiotensin II. Angiotensin II is an octapeptide
with the sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe. What will its net charge
be at pH 7?
OA) -2
B) -1
Oco
OD)
D) +
OE) +2
Transcribed Image Text:Angiotensin Converting Enzyme (ACE) is the target of ACE inhibitors such as captopril that are used therapeutically to control blood pressure. The enzyme ACE converts angiotensin I to angiotensin II. Angiotensin II is an octapeptide with the sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe. What will its net charge be at pH 7? OA) -2 B) -1 Oco OD) D) + OE) +2
A competitive inhibitor diminishes the rate of catalysis:
A)
By reducing the proportion of enzyme molecules bound to a
substrate.
B) By altering the shape of the active site of the enzyme
OC) By binding to a regulatory subunit
OD) By enhancing the interaction between enzyme and reaction product
Transcribed Image Text:A competitive inhibitor diminishes the rate of catalysis: A) By reducing the proportion of enzyme molecules bound to a substrate. B) By altering the shape of the active site of the enzyme OC) By binding to a regulatory subunit OD) By enhancing the interaction between enzyme and reaction product
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