A researcher studying late-onset Alzheimer's disease is interested in a gene, called ApoE, that codes for a neuronal protein with many different variants. The boxes in this diagram represent the ApoE coding sequence. The ATG start codon is located in exon 1. The lines between exons represent introns. Which of the following alternative mRNA splicing events would likely result in the production of a functional protein variant? Exon 1 Exon 2 Exon 3 Exon 4 5' UTR 3' UTR 3' UTR Removal of Exon 4 only Removal of any one Exon Removal of either Exon 3 or Exon 4 but not both Removal of Exon 3 only Removal of Exon 1 only

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