An article in Industrial and Engineering Chemistry (“More on Planning Experiments to Increase Research Efficiency,” 1970, pp. 60-65) uses a 25-2 design to investigate the effect of A = condensation, B = amount of material 1, C = solvent volume, D = condensation time, and E = amount of material 2 on yield.  The results obtained are as follows: e = 23.2 ad = 16.9 cd = 23.8 bde =

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