Activated protein kinase C (PKC) can lead to the modification of the membrane lipids in the vicinity of the active PKC. You have discovered the enzyme activated by PKC that mediates the lipid modification. You call the enzyme Rafty and demonstrate that activated PKC directly phosphorylates Rafty, activating it to modify the plasma membrane lipids in the vicinity of the cell where PKC is active. Explain how each of the following will affect the lipid modification: A. a Ca2+ channel in the endoplasmic reticulum with an increased affinity for IP3 B. a mutation in the gene that encodes Rafty such that the enzyme can no longer be phosphorylated by PKC
Activated protein kinase C (PKC) can lead to the modification of the membrane lipids in the vicinity of the active PKC. You have discovered the enzyme activated by PKC that mediates the lipid modification. You call the enzyme Rafty and demonstrate that activated PKC directly phosphorylates Rafty, activating it to modify the plasma membrane lipids in the vicinity of the cell where PKC is active. Explain how each of the following will affect the lipid modification: A. a Ca2+ channel in the endoplasmic reticulum with an increased affinity for IP3 B. a mutation in the gene that encodes Rafty such that the enzyme can no longer be phosphorylated by PKC
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Transcribed Image Text:Activated protein kinase C (PKC) can lead to the modification of the membrane lipids in the vicinity of the
active PKC. You have discovered the enzyme activated by PKC that mediates the lipid modification. You
call the enzyme Rafty and demonstrate that activated PKC directly phosphorylates Rafty, activating it to
modify the plasma membrane lipids in the vicinity of the cell where PKC is active. Explain how each of the
following will affect the lipid modification:
A. a Ca2+ channel in the endoplasmic reticulum with an increased affinity for IP3
B. a mutation in the gene that encodes Rafty such that the enzyme can no longer be phosphorylated by
PKC
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