According to the Michaelis–Menten equation, when an enzyme is combined with a substrate of concentration s (in millimolars), the reaction rate (in micromolars/min) is As R(s) = (A, K constants) K +s (a) Show, by computing lim R (s), that A is the limiting reaction rate as the concentration s approaches oo. s→∞ (b) Show that the reaction rate R(s) attains one-half of the limiting value A when s = K. (c) For a certain reaction, K = 1.25 mM and A = 0.1. For which concen- tration s is R(s) equal to 75% of its limiting value?

Calculus: Early Transcendentals
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Chapter1: Functions And Models
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According to the Michaelis–Menten equation, when an enzyme is
combined with a substrate of concentration s (in millimolars), the reaction
rate (in micromolars/min) is
As
R(s) =
(A, K constants)
K +s
(a) Show, by computing lim R (s), that A is the limiting reaction rate as
the concentration s approaches oo.
s→∞
(b) Show that the reaction rate R(s) attains one-half of the limiting value
A when s = K.
(c) For a certain reaction, K = 1.25 mM and A = 0.1. For which concen-
tration s is R(s) equal to 75% of its limiting value?
Transcribed Image Text:According to the Michaelis–Menten equation, when an enzyme is combined with a substrate of concentration s (in millimolars), the reaction rate (in micromolars/min) is As R(s) = (A, K constants) K +s (a) Show, by computing lim R (s), that A is the limiting reaction rate as the concentration s approaches oo. s→∞ (b) Show that the reaction rate R(s) attains one-half of the limiting value A when s = K. (c) For a certain reaction, K = 1.25 mM and A = 0.1. For which concen- tration s is R(s) equal to 75% of its limiting value?
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