A. The following shows a DNA fragment with a 2. operator. Circled bases make direct contacts with repressor protein el and the underlined base pairs are repositioned upon cl binding suh that they become more exposed to the surrounding environment. Describe in detail how you would perform a dimethyl sulfate (DMS) footprinting assay on this fragment and show the expected results (on a gel) with and without cl. (Note: the fragment 25 base-pairs in length). You can assume that the top and bottom strands are individually radiolabeled to start with (i.e. you don't have to explain how you would phosphorylate them with radioactive ATP). GTCACGIOTGACGIACGTACGTACGICATACOTGAC CAGTOCATACTGCATOCATGO®I@CAGTOIGCAOTG

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