a. Estimate creatinine clearances for each individual. b. All patients are receiving intravenous administrations of an antibiotic to treat an infection. The drug is cleared entirely by renal elimination (fe= 1). Patient A (an otherwise healthy adult) is receiving 100 mg of the drug every 4 hours. State what possible adjustment(s) to the dosage regimen may be required to achieve the same steady-state concentration for patient C?
a. Estimate creatinine clearances for each individual. b. All patients are receiving intravenous administrations of an antibiotic to treat an infection. The drug is cleared entirely by renal elimination (fe= 1). Patient A (an otherwise healthy adult) is receiving 100 mg of the drug every 4 hours. State what possible adjustment(s) to the dosage regimen may be required to achieve the same steady-state concentration for patient C?
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Homework Assignment
1. Data were taken from charts of three hospitalized individuals:
A
male
Gender
Age (y)
55
Weight (kg)
80
Height (cm)
178
SCR (m/dL)
0.9
a.
Estimate creatinine clearances for each individual.
b. All patients are receiving intravenous administrations of an antibiotic to treat an
infection. The drug is cleared entirely by renal elimination (fe= 1). Patient A (an
otherwise healthy adult) is receiving 100 mg of the drug every 4 hours. State what
possible adjustment(s) to the dosage regimen may be required to achieve the same
steady-state concentration for patient C?
B
female
65
55
148
2.3
C
male
4
16
105
1.7
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