a) Which molecule(s) could successfully form Grignard reagents without any issues? A) ia D) B) CI سلم C) Br OH E) Two of these could successfully form Grignard reagents
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
, contains a ketone group and a chloride atom.
B) , contains an ether group and a bromide atom.
C) , contains an alcohol group and a bromide atom.
D) , contains an aromatic benzene ring and a chloride atom.
E) Two of these could successfully form Grignard reagents.
**Explanation:**
Grignard reagents are highly reactive chemicals typically formed by the reaction of an alkyl or aryl halide with magnesium metal in dry ether. Grignard reagents are sensitive to functional groups with active hydrogen, such as alcohols or acids, and cannot be formed from substances containing these groups. Additionally, carbonyl functional groups may interfere with Grignard formation as they can react with the Grignard reagent itself.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1b6d2ff7-3f11-4290-8056-7bb948a1665a%2Fbee8bd2d-2b85-4df8-addb-9d776ef63193%2Fqfpay5j_processed.jpeg&w=3840&q=75)
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