A surge function is a function of the form f(t) = At" e( bt) The values A, n, and b are the parameters of the function. This function accurately represents the way a drug interacts in the bloodstream. Studying this function is essential to doctors and pharmacists because it allows them to administer dosages of medicine correctly A drug dose is being designed for a 100kg female patient. The amount of the drug in the patient's bloodstream after t hours, measured in nanograms per milliliter (ng/ml) is given by a surge function.
A surge function is a function of the form f(t) = At" e( bt) The values A, n, and b are the parameters of the function. This function accurately represents the way a drug interacts in the bloodstream. Studying this function is essential to doctors and pharmacists because it allows them to administer dosages of medicine correctly A drug dose is being designed for a 100kg female patient. The amount of the drug in the patient's bloodstream after t hours, measured in nanograms per milliliter (ng/ml) is given by a surge function.
A surge function is a function of the form f(t) = At" e( bt) The values A, n, and b are the parameters of the function. This function accurately represents the way a drug interacts in the bloodstream. Studying this function is essential to doctors and pharmacists because it allows them to administer dosages of medicine correctly A drug dose is being designed for a 100kg female patient. The amount of the drug in the patient's bloodstream after t hours, measured in nanograms per milliliter (ng/ml) is given by a surge function.
For number one, you need to find A. For extended delay type, input t as 24 then equal it to 0 (in this case, 10 is the limit for the extended type. Look at the graph) Then isolate A by dividing the function, so it should be 10/ (surge function). You can't do the same with medium and rapid since their limits are 100 and requires different time t value You need to take derivative to get t and then like before input the t value to the specific function and equal it to 100 to get A Number 2, I'm not too sure, but you need to compute integrals to get the area under the curve. The area is the maximum treatment effect. For Number 3a do another integral from O to 24 for the chosen delay type. For 3b compute an integral from. 24 to infinity. You're allowed to use a calculator for number 1 and 2 only via instructions provided I believe you must show your work for number 3 so I hope you are good doing improper integrals and integration by parts.
Transcribed Image Text:A surge function is a function of the form
f(t) = At" e( bt)
The values A, n, and b are the parameters of the function.
This function accurately represents the way a drug interacts in the bloodstream. Studying
this function is essential to doctors and pharmacists because it allows them to administer
dosages of medicine correctly
A drug dose is being designed for a 100kg female patient. The amount of the drug in the
patient's bloodstream after t hours, measured in nanograms per milliliter (ng/ml) is given
by a surge function.
Any positive value of A can be achieved by increasing or decreasing the amount of
medicine given. However, depending on the type of delayed release mechanism selected
there are choices possible for the value of the pair (n,b): The achievable pairs are listed in
the table below.
Delay Type n value b value
Extended 2
0.2
Medium
3
0.4
Rapid
3
0.6
The medical requirements for the treatment are:
• The dose (in ng/ml) may not exceed 100 at any time.
The dose must fall to be at or below 10 ng/ml by 24 hours.
Within these parameters, the treatment effect will be measured in ng/ml-hours. (1
ng/ml concentration for 1 hour is 1 ng/ml-hour of treatment). The objective is to obtain
the maximum possible treatment effect while ensuring the requirements are met.
Transcribed Image Text:Project instructions
1. For each Delay Type, determine the value of A (dosage amount) that maximizes treat-
ment effect for that Delay Type while meeting medical requirements.
2. Determine which Delay Type (assuming optimal dosage) will maximize treatment ef-
fect.
3. For the Delay Type and dosage level you selected,
(a) determine the exact treatment effect over the first 24 hours.
(b) determine the residual treatment effect for time after the first 24 hours.
Note: For parts (1) and (2) you may use numerical tools (computer/calculator/etc) as
long as you reach a decimal accuracy of two decimal places, and clearly describe exactly how
you use those tools to obtain your result. You may also find a graphing tool to be useful
overall for visualizing the problem. A graph for the "Rapid" delay pattern is available here:
https://www.desmos.com/calculator/epsu7qu2t9
With differentiation, one of the major concepts of calculus. Integration involves the calculation of an integral, which is useful to find many quantities such as areas, volumes, and displacement.
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