Musculoskeletal System
The musculoskeletal system, also called the locomotor system, is an organ system that gives humans and animals the ability to move using their muscular and skeletal systems. It provides stability, form, support, and movement to the body. The skeleton is composed of bones (skeleton), muscles, cartilage, tendons, ligaments, joints, and other connective tissue that supports and binds tissues and organs together. The musculoskeletal system is subdivided into two broad systems, such as the muscular system and the skeletal system.
Skeletal structure
The skeletal system is the core framework of the human body. The skeletal structure comprises bones and connective tissue, including cartilage, ligaments, and tendons. The skeletal structure of our body acts as a support structure. It maintains the body's shape and is responsible for its movement, blood cell formation, protection of organs, and mineral storage. The skeletal system is referred to as the musculoskeletal system.
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Nicotinic acetylcholine receptors, abbreviated as nAChRs, represent a pivotal component of the nervous system and can be categorized into two primary groups: muscle receptors, strategically positioned at the skeletal neuromuscular junction, and neuronal receptors, which are distributed extensively throughout the nervous system. The architectural structure of these receptors is notably intricate, comprising five subunits meticulously arranged in a ring formation encircling a narrow membrane pore. Activation of these receptors transpires upon binding with specific agonists, such as acetylcholine or nicotine. This binding event induces the stabilization of open and desensitized states, consequently facilitating the transit of positively charged ions through the channel. Typically, these channels exhibit swift and persistent opening, generally maintaining their open state until the agonist disperses, which typically occurs within the span of 1 millisecond.
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