a-Santonin, isolated from the flower heads of certain species of Artemisia, is an anthelmintic (meaning against intestinal worms). This terpene is used in oral doses of 60 mg to rid the body of roundworms such as Ascaris lumbricoides. It has been es- timated that over one-third of the world's population is infested with these slender, threadlike parasites. CH3 CH3 a-Santonin CH3

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Locate the three isoprene units in santonin and show how the carbon skeleton of farnesol might be coiled and then cross-linked to give santonin. Two different coiling patterns of the carbon skeleton of farnesol can lead to santonin. Try to find
them both.

a-Santonin, isolated from the flower heads of certain species of Artemisia, is an
anthelmintic (meaning against intestinal worms). This terpene is used in oral doses
of 60 mg to rid the body of roundworms such as Ascaris lumbricoides. It has been es-
timated that over one-third of the world's population is infested with these slender,
threadlike parasites.
CH3
CH3
a-Santonin
CH3
Transcribed Image Text:a-Santonin, isolated from the flower heads of certain species of Artemisia, is an anthelmintic (meaning against intestinal worms). This terpene is used in oral doses of 60 mg to rid the body of roundworms such as Ascaris lumbricoides. It has been es- timated that over one-third of the world's population is infested with these slender, threadlike parasites. CH3 CH3 a-Santonin CH3
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