A protein-ligand complex has a Kd value of 1 mM at 25°C, at 37°C Kd decreases to 100 μM. What is ΔS and ΔH of binding at 37°C? Assume ΔCp of the binding is 0 over the temperature range. (Hint: This means that ΔS and ΔH are constant over the temperature range).

A protein-ligand complex has a Kd value of 1 mM at 25°C, at 37°C Kd decreases to 100 μM. What is ΔS and ΔH of binding at 37°C? Assume ΔCp of the binding is 0 over the temperature range. (Hint: This means that ΔS and ΔH are constant over the temperature range).

General Chemistry - Standalone book (MindTap Course List)

11th Edition

ISBN:9781305580343

Author:Steven D. Gammon, Ebbing, Darrell Ebbing, Steven D., Darrell; Gammon, Darrell Ebbing; Steven D. Gammon, Darrell D.; Gammon, Ebbing; Steven D. Gammon; Darrell

Publisher:Steven D. Gammon, Ebbing, Darrell Ebbing, Steven D., Darrell; Gammon, Darrell Ebbing; Steven D. Gammon, Darrell D.; Gammon, Ebbing; Steven D. Gammon; Darrell

Chapter18: Thermodynamics And Equilibrium

Section: Chapter Questions

Problem 18.99QP: a Calculate K1, at 25C for phosphoric acid: H3PO4(aq)H+(aq)+H2PO4(aq) b Which thermodynamic factor...

See similar textbooks

Related questions

Q: A = 0.344 (absorption of light) ℓ = 1.0 cm Stock solution of KSCN and mM Fe(NO3)3 : 5 mL The…

A: #Question-1: The balanced equation for the reaction of Fe3+(aq) and SCN-(aq) is: Fe3+(aq) + SCN-(aq)…

Q: Consider the insoluble compound nickel(II) carbonate , NiCO3 . The nickel ion also forms a complex…

A: answer of the question is given below

Q: A = 0.344 (absorption of light) ℓ = 1.0 cm Stock solution of KSCN and mM Fe(NO3)3 : 5 mL The…

A: #Question-1: Pure water has very less color-absorbing species or contaminants than iron nitrate.…

Q: The propionate ion, CH3CH2COO–, reacts with water as a weak base: CH3CH2COO–, (aq) + H2O(l) ⇄…

A: Answer- 0.0000211 M (without scientific notation) 2.11× 10-5 M (with scientific notation)…

Q: calculate the value of Keq.

Q: Chromium(VI) forms two different oxyanions, the orange dichromate ion, Cr20,2-, and the yellow…

A: Chromate Ion (Yellow) is a salt of Chromic Acid. Dichromate Ion (Orange) is a salt of Dichromic…

Q: Given that the solubility reaction for calcium phosphate is…

A: Given Reaction Ca3(PO4)2(s)⇌3Ca2+(aq.)+2PO43−(aq.) Observation The addition of acid increase the…

Q: Given the following ionic equilibria and their K values: AgBr(s) ⇌…

Q: A saturated solution of Mg3(PO4)2 has a concentration of 0.939 mg per liter. Calculate the…

A: The solubility product constant (Ksp) represents the solubility of products at equilibrium for…

Q: Potassium Ferrioxalate is mixed with in 50 mL of 1 M H2SO4 In a beaker , it is then placed one-half…

A: The chemical effects of light are studied in photochemistry, which is a branch of chemistry. In…

Q: Given that Ka for HC1O is 4.0 × 10-8 at 25 °C, what is the value of K, for ClO¯ at 25 °C? Kp = Given…

A: (1) Given that - Ka for HClO = 4.0×10-8 Temperature = 25°C Then, from following formula - Ka .…

Q: Co(NH,), complex K,= 1.58 × 10 at 25 °C. For the aqueous %3D Suppose equal volumes of 0.0028M…

A: As Equal volume are taken Concentration of Co(NO3)3 = 0.0028 M2 = [Co3+]Concentration of Co(NO3)3…

Q: For the aqueous complex at Fe (CN)6]4-complex Kf= 1.0 x 10^35 Suppose equal volumes of 0.0062M…

A: Given data:

Q: Which is the correct Ksp expression for Cr(OH)3(s) dissolving in water?

A: we need to write the expression for Ksp for Cr(OH)3(s)

Q: the equilibrium constant (K) is a quantitative measurement of the extent to which a chemical or…

A: Given: ℓ = 1.0 cm ε =2867 M The 3-trial absorption solution (A): Total Volume of solution = 10…

Q: How

A: Dear student I have given answer to your question in the image format.

Q: Consider the following equilibrium system: Ag+(aq) + 2NH3(aq) D Ag(NH3)2+(aq)…

A: The equilibrium constant (Keq) of a reaction is the ratio of product of molar concentrations of…

Q: Using thermodynamic data to calculate K Using any data you can find in the ALEKS Data resource,…

Q: Consider the insoluble compound silver chloride, AgCl. The silver ion also forms a complex with…

Q: You studied the following equilibrium to determine the value of K, for the system: Fe³+ (aq) + SCN-…

A: Definition of equilibrium constant - The ratio between the amount of reactant and the amount of…

Q: Consider the insoluble compound iron (II) carbonate, FeCO3. The iron(II) ion also forms a complex…

Q: f 4.00 g of CuSO4 are dissolved in 8.5 × 102 mL of 0.25 M NH3 solution, what are the concentrations…

A: To find concentration of Cu2+, [Cu(NH3)4]2+, and NH3 in the solution when 4.00 g of CuSO4 is…

Q: Consider The Following Reaction: CaCO3(S) + 2HCl(Aq) = CaCl2(Aq) + H2O(L) + CO2(G) Write down the…

Q: lating Ke to Kp ?

Q: 3. The free energy change for the formation of the complex ion AIF6 is –140. kJ at 25 °C. What is…

A: The relation between free energy and equilibrium constant is shown below: ∆G0 =-RT lnKeq where; R =…

Q: The blue complex Cu(H, O);+ and the yellow complex CuCl exist in equilibrium. Cu(H,O)*(aq) + 4…

A: We have added LiCl to the equilibrium, we have to tell the effect of this.

Q: Compare the solubility of ferrihydrite (Fe(OH)3) and goethite (FeOOH). Dissolution Reactions: (A)…

A: Dissolution Reactions: (A) Fe(OH)3 + 3 H+ ------> Fe3+ + 3 H2O given, Ksp = 8.8 x 10^4 , ΔGr =…

Q: The formation of the iron(III) thiocyanate complex ion is an exothermic equilibrium system. For each…

A: In chemical equilibrium is a state where the rate of reaction in the forward direction becomes equal…

Concept explainers

Atomic Structure

The basic structure of an atom is defined as the component-level of atomic structure of an atom. Precisely speaking an atom consists of three major subatomic particles which are protons, neutrons, and electrons. Many theories have been stated for explaining the structure of an atom.

Shape of the D Orbital

Shapes of orbitals are an approximate representation of boundaries in space for finding electrons occupied in that respective orbital. D orbitals are known to have a clover leaf shape or dumbbell inside where electrons can be found.

Question

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

Step 2

Step 3

Step 4

Step 5

Trending now

This is a popular solution!

Step by step

Solved in 5 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

Adult hemoglobin can carry up to four oxygen molecules per hemoglobin molecule, with the addition of oxygen proceeding in a step-wise fashion. For the third step, the value of the equilibrium constant is Keq=5.86E-4 although the reaction has a delta H value of -2.9 kJ/mol. (The system is not at room temperature. Calculate delta G for this process.
Irn/takeAssignment/takeCovalentActivity.do TripAdvisor Facebook [Review Topics] [References] Use the References to access important values if needed for this question. The equilibrium constant, K, for the following reaction is 55.6 at 698 K. H2 (g) + 1, (g)=2 HI (g) Calculate the equilibrium concentrations of reactants and product when 0.224 moles of H, and 0.224 moles of I, are introduced into a 1.00 L vessel at 698 K. [H2] = M [1] = [HI] = M M Submit Answer Retry Entire Group 1 more group attempt remaining Next Email Instructor Save and Exit Ceng
The molecular complex between silver ion and cyanide ion forms by the reactionAg+(aq) + 2 CN-(aq) ⇌ Ag(CN)2-(aq) Kf = 1.0 x 10^21A solution initially has [Ag+] = 2.0 x 104 M, and [CN-] = 0.0400 M. What will be the concentration ofAg+ ion at equilibrium?
Which is the correct Ksp expression for Cr(OH)3(s) dissolving in water?
solid, 0.689 M calcium (Ca²+) aqueous solution, and 0.245 M phosphate A chemist fills a reaction vessel with 0.999 g calcium phosphate (Ca (PO 3- (PO₁³-) 4 aqueous solution at a temperature of 25.0°C. Under these conditions, calculate the reaction free energy AG for the following chemical reaction: 2+ 3- Ca₂ (PO) (s) 3Ca²+ (aq) +2PO₂ (aq) 4 2 Use the thermodynamic information in the ALEKS Data tab. Round your answer to the nearest kilojoule. ៣៤ kJ X Ś ?
GIVEN: Compare the solubility of ferrihydrite (Fe(OH)3) and goethite (FeOOH). Dissolution Reactions: (A) Fe(OH)3 3 H+ à Fe3+ + 3 H2O with Ksp = 8.8 x 10^4 ΔGr = -28 KJ/mol (B) FeOOH + 3 H+ à Fe3+ + 2 H2O with Ksp = 8.8 x 10^-2 ΔGr = 6 KJ/mol ΔGo (KJ/mol): Fe(OH)3 = -692 FeOOH = -489 H+ = 0 Fe3+ = -9 H2O = -237 QUESTION: How much Fe3+ from ferrihydrite would dissolve at pH 2 and 7? How much Fe3+ from goethite would dissolve at pH 2 and 7?
10 In a dilute nitric acid solution, Fe" reacts with thiocyanate ion (SCN ) to form a dark-red complex: [Fe(H,O),J + SCN = H,0 + [Fe(H-0),NCS]*" The equilibrium concentration of (Fe(H-0),NCS]" may be determined how darkly colored the solution is (measured by a spectrometer). In one such experiment, 1.0 mL of 0.20 M Fe(NO), was mixed with 1.0 mL of 1.0 X 10 M KSCN and 8.0 mL of dilute HNO, The color of the solution quanti- tatively indicated that the [Fe{H_O),NCS] concen- tration was 7.3 x 10 M. Calculate the formation constant for [Fe(H,O),NCS]
Hemoglobin, abbreviated Hgb, reacts with a certain oxide, XO, and oxygen gas, 02. Consider the following reactions and approximate standard free energy changes: ΔG° = -70.00 kJ AG° = -93.4 kJ Hgb + 02 = Hgb02 Hgb + XO = HgbXO Using these data, estimate the equilibrium constant value at 25 °C for the following reaction: Hgbo2 + XO = HgbXO + 02 Please make sure to use 4 sig. figs throughout your calculations. Answer: -23.40 The correct answer is: 12634.20
Consider the following equilibrium system: Ag+(aq) + 2NH3(aq) D Ag(NH3)2+(aq) + energy If the equilibrium concentrations are as follows, what is the value of Keq? [Ag+] = 2.0M , [NH3] = 6.0 M , [Ag(NH3)2+] = 8.0M
Calculate the K, of the reaction of Ag" binding with Ligand L Ag"(aq) + Llaq) → AgL*(aq) K= ? Refer to the coupled equilibria shown below. (1) Agʻ(aq) + L(aq) → AgL*(aq) K= ? (2) AgClls) = Ag"(aq) + CI (aq) K 1.83 x 10 10 %3D (3) AgCl(s) + Llaq)→ AgL*(aq) + Cl (aq) K= K¢ Kgp =23.7 0 1.30 e 11 0 1.30 e-11 0 7.72 e-12
The blue complex Cu(H,O);+ and the yellow complex CuCl- exist in equilibrium. Cu(H, O);+(aq) + 4 CI¯(aq) = CuCl (aq) + 4 H, O(1) Upon addition of LiCl to this equilibrium in solution, which observation would be expected? The solution turns blue. The solution turns yellow. The Cu2+ salts precipitate out of solution. The volume of water decreases. Incorrect O O O
Given the reaction: 6CO2+ 6H2O→ C6H12O6 + 6O2 ΔG°f CO2 = −394.39 kJ/mol ΔG°fH2O = −237.14 kJ/mol ΔG°fC6H12O6 = -2870 kJ/mol ΔG°fO2 = 0 What will be the ΔG at equilbrium?

SEE MORE QUESTIONS

Recommended textbooks for you

General Chemistry - Standalone book (MindTap Cour…

Chemistry

ISBN:

9781305580343

Author:

Steven D. Gammon, Ebbing, Darrell Ebbing, Steven D., Darrell; Gammon, Darrell Ebbing; Steven D. Gammon, Darrell D.; Gammon, Ebbing; Steven D. Gammon; Darrell

Publisher:

Cengage Learning

General Chemistry - Standalone book (MindTap Cour…

Chemistry

ISBN:

9781305580343

Author:

Steven D. Gammon, Ebbing, Darrell Ebbing, Steven D., Darrell; Gammon, Darrell Ebbing; Steven D. Gammon, Darrell D.; Gammon, Ebbing; Steven D. Gammon; Darrell

Publisher:

Cengage Learning

SEE MORE TEXTBOOKS