Homework Help is Here – Start Your Trial Now!
Science
Chemistry
a) Propose a mechanism for the decarboxylation of THCA under acidic conditions. Hint: first the "enol" automerizes to the ketone, then decarboxylation occurs. OH THCA OH H3O+ heat OH $5 THC

a) Propose a mechanism for the decarboxylation of THCA under acidic conditions. Hint: first the "enol" automerizes to the ketone, then decarboxylation occurs. OH THCA OH H3O+ heat OH $5 THC

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
See similar textbooks
icon
Related questions
Question
THC (tetrahydrocannabinol) is the primary psychoactive component of cannabis. THC is produced from THCA (tetrahydrocannabinolic acid) when THCA is heated (i.e. when cannabis leaves are smoked or cooked). a) Propose a mechanism for the decarboxylation of THCA under acidic conditions. Hint: first the "enol" tautomerizes to the ketone, then decarboxylation occurs. OH THCA OH H3O+ heat OH THC b) Which part of the mechanism do you think occurs more readily: tautomerization to the ketone or decarboxylation? Why?
Transcribed Image Text:THC (tetrahydrocannabinol) is the primary psychoactive component of cannabis. THC is produced from THCA (tetrahydrocannabinolic acid) when THCA is heated (i.e. when cannabis leaves are smoked or cooked). a) Propose a mechanism for the decarboxylation of THCA under acidic conditions. Hint: first the "enol" tautomerizes to the ketone, then decarboxylation occurs. OH THCA OH H3O+ heat OH THC b) Which part of the mechanism do you think occurs more readily: tautomerization to the ketone or decarboxylation? Why?
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps with 1 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Ammonium Salts
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY
SEE MORE TEXTBOOKS