Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:**Question 21**
A plot of activity versus pH for an enzyme that functions in the cytosol of a cell at pH of about 7 would probably:
- A. Show the highest activity between pH of 4 and 6
- B. Show the lowest activity at pH of about 7 to 8
- C. Have the highest activity around a pH of 7
- D. Look about the same as an enzyme like pepsin that functions in the stomach at a pH of about 1
- E. Show the same activity at every pH between 4 and 10

Transcribed Image Text:**Question 22**
The enzyme acetylcholine esterase catalyzes the hydrolysis of acetylcholine, producing choline and acetate. It has a mechanism that involves a catalytic triad in which a nucleophilic serine first attacks the C=O of the ester linkage in acetylcholine. When acetylcholine esterase is exposed to diisopropylphosphofluoridate, one can therefore expect:
- **A.** Diisopropylphosphofluoridate to be bound loosely (reversibly) at the active site of acetylcholinesterase
- **B.** An increase in the hydrolysis of acetylcholine
- **C.** A decrease in the activity of acetylcholine esterase
- **D.** Covalent bonds to form between diisopropylphosphofluoridate and acetylcholine
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