A pharmacist is asked to compound the following formula for the preparation of 100 capsules: 200 mg Estriol 25 mg Estrone 25 mg Estradiol 10 g Methocel E4M 23.75 g Lactose uibo2 Using a balance that has an SR of 6 mg, the aliquot method of weighing, lactose as the diluent, a dilution factor of 6, and an error in weighing of 4%, show how the correct quantity of estrone can be obtained to accurately compound the formula. a) Calculate the MWQ Umg/0.04 = 150 mg b) Calculate the amount of active drug to weigh (200+25+25₁ +10 1550 c) Calculate the total weight of mixture 900m-150 HW.EI d) Calculate the amount of diluent needed 150 my e) Calculate the amount of aliquot mixture to weigh that contains 25 mg of drug substance 150mg
A pharmacist is asked to compound the following formula for the preparation of 100 capsules: 200 mg Estriol 25 mg Estrone 25 mg Estradiol 10 g Methocel E4M 23.75 g Lactose uibo2 Using a balance that has an SR of 6 mg, the aliquot method of weighing, lactose as the diluent, a dilution factor of 6, and an error in weighing of 4%, show how the correct quantity of estrone can be obtained to accurately compound the formula. a) Calculate the MWQ Umg/0.04 = 150 mg b) Calculate the amount of active drug to weigh (200+25+25₁ +10 1550 c) Calculate the total weight of mixture 900m-150 HW.EI d) Calculate the amount of diluent needed 150 my e) Calculate the amount of aliquot mixture to weigh that contains 25 mg of drug substance 150mg
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:. A pharmacist is asked to compound the following formula for the preparation of 100 capsules:
Estriol
Estrone
Estradiol
Methocel E4M
Lactose
200 mg
25 mg
25 mg
10 g
23.75 g
Using a balance that has an SR of 6 mg, the aliquot method of weighing, lactose as the diluent, a
dilution factor of 6, and an error in weighing of 4%, show how the correct quantity of estrone
can be obtained to accurately compound the formula.
9-613,0
umg/0.04 = 150 mg os
2
ibo2
a) Calculate the MWQ
b) Calculate the amount of active drug to weigh (200+25+25+10 155O
c) Calculate the total weight of mixture 900 may-150
SHT
d) Calculate the amount of diluent needed 150 m
e) Calculate the amount of aliquot mixture to weigh that contains 25 mg of drug substance
I
150mg
CH
49
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