A patient was admitted to the hospital with suspicion of malaria. After the examination was complete and the diagnosis confirmed, the patient was prescribed primaquine, an antimalarial drug. The drug caused a complication and led to hemolysis of erythrocytes and a decrease in the total number of circulating erythrocytes. The serening showed a glucose-6-phosphate dehydrogenase defect. Explain why the enzyme deficiency led to red blood cel hemolysis in the patient taking primaquine (the drug induces the formation of free radicals in cells). To answer: a) write a diagram ofthe process involving glucose-6-phosphate dehydrogenase; b) indicate the coenzyme of the enzyme and the reaction that includes its reduced coenzyme; c) explain the cause of RBC hemolysis in reduced coenzyme deficiency.
A patient was admitted to the hospital with suspicion of malaria. After the examination was complete and the diagnosis confirmed, the patient was prescribed primaquine, an antimalarial drug. The drug caused a complication and led to hemolysis of erythrocytes and a decrease in the total number of circulating erythrocytes. The serening showed a glucose-6-phosphate dehydrogenase defect. Explain why the enzyme deficiency led to red blood cel hemolysis in the patient taking primaquine (the drug induces the formation of free radicals in cells). To answer: a) write a diagram ofthe process involving glucose-6-phosphate dehydrogenase; b) indicate the coenzyme of the enzyme and the reaction that includes its reduced coenzyme; c) explain the cause of RBC hemolysis in reduced coenzyme deficiency.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A patient was admitted to the hospital with suspicion of malaria. After the examination was complete and the diagnosis confirmed, the patient was prescribed primaquine, an antimalarial drug. The drug caused a complication and led to hemolysis of erythrocytes and a decrease in the total number
of circulating erythrocytes. The serening showed a glucose-6-phosphate dehydrogenase defect. Explain why the enzyme deficiency led to red blood cel hemolysis in the patient taking primaquine (the drug induces the formation of free radicals in cells). To answer:
a) write a diagram ofthe process involving glucose-6-phosphate dehydrogenase; b) indicate the coenzyme of the enzyme and the reaction that includes its
reduced coenzyme;
c) explain the cause of RBC hemolysis in reduced coenzyme deficiency.
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