Answered: A patient suffering from fatigue and…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Answer the following questions: 1. A patient suffering from fatigue and pallor has been diagnosed of megaloblastic anemia and was given vitamin B12 (cobalamin) as a supplement. Megaloblastic anemia occurs due to reduced activity of methionine synthase, an enzyme responsible for the conversion of homocysteine to methionine. What role is played by vitamin B12 (cobalamin) to methionine synthase? A. apoenzyme B. coenzyme C. holoenzyme D. isoenzymes E. cofactor 2. A given substrate may be acted upon by a number of different enzymes, each of which uses the same substrate(s) and produces the same product(s). The individual numbers of a set of enzymes sharing such characteristics are known as ___, which are of clinical interest because they can be used as molecular markers of tissue damage. A. Cofactor B. Coenzyme C. Holoenzyme D. Apoenzyme E. Isoenzymes 3. Succinic acid dehydrogenase is an enzyme which catalyzes the oxidation of succinic acid during cell respiration. If malonic acid is added to the system, the rate of reaction is reduced. An increase in the substrate concentration, succinic acid, increases the rate of reaction again. One possibility for is the similar molecular configuration of malonic acid with succinic acid. If this is true, then the inhibition of malonic acid is most likely an example of ___ inhibition. A. noncompetitive B. competitive C. uncompetitive D. irreversible

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