A new drug (Compound Y) is developed for treatment of cancer. Initial studies on isolated cells show that Compound Y decreases cancer cell viability by 95%. However, when Compound Y is tested on ventricular cardiac myocytes it is observed that it causes a significant reduction in delayed rectifier K+ channel current. Why could Compound Y NOT be taken forward to clinical trials?
A new drug (Compound Y) is developed for treatment of cancer. Initial studies on isolated cells show that Compound Y decreases cancer cell viability by 95%. However, when Compound Y is tested on ventricular cardiac myocytes it is observed that it causes a significant reduction in delayed rectifier K+ channel current. Why could Compound Y NOT be taken forward to clinical trials?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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please choose a right answer from the followng points.
Transcribed Image Text:A new drug (Compound Y) is developed for treatment of
cancer. Initial studies on isolated cells show that
Compound Y decreases cancer cell viability by 95%.
However, when Compound Y is tested on ventricular
cardiac myocytes it is observed that it causes a significant
reduction in delayed rectifier K+ channel current. Why
could Compound Y NOT be taken forward to clinical trials?
Compound Y is likely to cause a shortening of the Q-T
interval
Compound Y is likely to induce conduction slowing and
QRS prolongation
Compound Y is likely to increase the risk of early
afterdepolarisations (EADS)
Compound Y is likely to trigger spontaneous Ca2+ release
from the sarcoplasmic reticulum (SR)
Compound Y is likely to promote re-entry circuit formation
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