(a) Find the proportion of subjects experiencing the primary outcome for both the sibutramine and placebo groups. (b) Can we safely use the large-sample confidence inter- val for comparing the proportions of sibutramine and placebo subjects who experienced the primary

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12. 18 Effects of an appetite suppressant. Subjects with pre-
existing cardiovascular symptoms who were receiving
sibutramine, an appetite suppressant, were found to be
at increased risk of cardiovascular events while taking
Transcribed Image Text:12. 18 Effects of an appetite suppressant. Subjects with pre- existing cardiovascular symptoms who were receiving sibutramine, an appetite suppressant, were found to be at increased risk of cardiovascular events while taking
chat
the drug. The study included 9804 overweight or obese
subjects with preexisting cardiovascular disease and/or
type 2 diabetes. The subjects were randomly assigned to
sibutramine (4906 subjects) or a placebo (4898 subjects)
in a double-blind fashion. The primary outcome mea-
text.
sted
rvey
line
sured was the occurrence of any of the following events:
nonfatal myocardial infarction or stroke, resuscitation
after cardiac arrest, or cardiovascular death. The primary
pro-
yes.
outcome was observed in 561 subjects in the sibutra-
17
rge-
mine group and 490 subjects in the placebo group."
(a) Find the proportion of subjects experiencing the
primary outcome for both the sibutramine and
placebo groups.
nce
ens
(b) Can we safely use the large-sample confidence inter-
val for comparing the proportions of sibutramine
and placebo subjects who experienced the primary
outcome? Explain.
es.
re-
ng
be
Transcribed Image Text:chat the drug. The study included 9804 overweight or obese subjects with preexisting cardiovascular disease and/or type 2 diabetes. The subjects were randomly assigned to sibutramine (4906 subjects) or a placebo (4898 subjects) in a double-blind fashion. The primary outcome mea- text. sted rvey line sured was the occurrence of any of the following events: nonfatal myocardial infarction or stroke, resuscitation after cardiac arrest, or cardiovascular death. The primary pro- yes. outcome was observed in 561 subjects in the sibutra- 17 rge- mine group and 490 subjects in the placebo group." (a) Find the proportion of subjects experiencing the primary outcome for both the sibutramine and placebo groups. nce ens (b) Can we safely use the large-sample confidence inter- val for comparing the proportions of sibutramine and placebo subjects who experienced the primary outcome? Explain. es. re- ng be
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