A Draw a mechanism and predict the product for the following reaction. In this case, H3O" must be used as a proton source instead of water. Explain why. B Using a Grignard reaction, show how you could prepare the following alcohol. Using a Grignard reaction, show how you could prepare the following alcohol. C. OH Select the reactants needed (you can assume there will be an aqueous workup). 12.52 1) xs MeMgBr 2) H₂O ? Identify the major product. о о 12.37b D Of the following, which represents a reasonable Grignard reaction disconnection in the retrosynthesis of the target molecule? Select all that apply. 0 ☐ 어 о D. OH ° D D of она он The conversion of 1-butanol to the given compound can be performed with some combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A 1) MeMgBr; 2) H₂O* C B 1) EtMgBr; 2) H₂O* DMP or PCC E. CH₂MgBr 0 о MgBr 0 MgBr Acid-catalyzed hydration of 3,3-dimethyl-1-butene produces 2,3-dimethyl-2-butanol. Show a mechanism for this reaction. 12.35a ect act H2, Lindlar's cat. conc. H2SO4, heat Na2Cr2O7, H2SO4, H₂O ட் Identify the most likely sequence of steps in the mechanism. O Nucleophilic attack, rearrangement, deprotonation, protonation. O Protonation, nucleophilic attack, rearrangement, deprotonation. O Protonation, rearrangement, nucleophilic attack, deprotonation. ◇ Nucleophilic attack, protonation, rearrangement, deprotonation. Identify reagents that can be used to achieve the following transformation. More than one answer may be correct. Select all that apply. 1) LiAlH4, 2) H₂O* Na2Cr2O7, H2SO4, H₂O PCC, CH2Cl2 NaBH4, MeOH OH
A Draw a mechanism and predict the product for the following reaction. In this case, H3O" must be used as a proton source instead of water. Explain why. B Using a Grignard reaction, show how you could prepare the following alcohol. Using a Grignard reaction, show how you could prepare the following alcohol. C. OH Select the reactants needed (you can assume there will be an aqueous workup). 12.52 1) xs MeMgBr 2) H₂O ? Identify the major product. о о 12.37b D Of the following, which represents a reasonable Grignard reaction disconnection in the retrosynthesis of the target molecule? Select all that apply. 0 ☐ 어 о D. OH ° D D of она он The conversion of 1-butanol to the given compound can be performed with some combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A 1) MeMgBr; 2) H₂O* C B 1) EtMgBr; 2) H₂O* DMP or PCC E. CH₂MgBr 0 о MgBr 0 MgBr Acid-catalyzed hydration of 3,3-dimethyl-1-butene produces 2,3-dimethyl-2-butanol. Show a mechanism for this reaction. 12.35a ect act H2, Lindlar's cat. conc. H2SO4, heat Na2Cr2O7, H2SO4, H₂O ட் Identify the most likely sequence of steps in the mechanism. O Nucleophilic attack, rearrangement, deprotonation, protonation. O Protonation, nucleophilic attack, rearrangement, deprotonation. O Protonation, rearrangement, nucleophilic attack, deprotonation. ◇ Nucleophilic attack, protonation, rearrangement, deprotonation. Identify reagents that can be used to achieve the following transformation. More than one answer may be correct. Select all that apply. 1) LiAlH4, 2) H₂O* Na2Cr2O7, H2SO4, H₂O PCC, CH2Cl2 NaBH4, MeOH OH
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Question
Transcribed Image Text:A
Draw a mechanism and predict the product for the following reaction. In this case, H3O" must be used as a proton source instead of
water. Explain why.
B
Using a Grignard reaction, show how you could prepare the following alcohol.
Using a Grignard reaction, show how you could prepare the following alcohol.
C.
OH
Select the reactants needed (you can assume there will be an aqueous workup).
12.52
1) xs MeMgBr
2) H₂O
?
Identify the major product.
о
о
12.37b
D
Of the following, which represents a reasonable Grignard reaction disconnection in the retrosynthesis of the target molecule?
Select all that apply.
0
☐
어
о
D.
OH
°
D
D
of
она
он
The conversion of 1-butanol to the given compound can be performed with some combination of the reagents listed below. Give the
necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one
correct solution, provide just one answer.
A
1) MeMgBr;
2) H₂O*
C
B
1) EtMgBr;
2) H₂O*
DMP or PCC
E.
CH₂MgBr
0
о
MgBr
0
MgBr
Acid-catalyzed hydration of 3,3-dimethyl-1-butene produces 2,3-dimethyl-2-butanol. Show a mechanism for this reaction.
12.35a
ect
act
H2, Lindlar's cat.
conc. H2SO4, heat
Na2Cr2O7, H2SO4, H₂O
ட்
Identify the most likely sequence of steps in the mechanism.
O Nucleophilic attack, rearrangement, deprotonation, protonation.
O Protonation, nucleophilic attack, rearrangement, deprotonation.
O Protonation, rearrangement, nucleophilic attack, deprotonation.
◇ Nucleophilic attack, protonation, rearrangement, deprotonation.
Identify reagents that can be used to achieve the following transformation. More than one answer may be correct.
Select all that apply.
1) LiAlH4, 2) H₂O*
Na2Cr2O7, H2SO4, H₂O
PCC, CH2Cl2
NaBH4, MeOH
OH
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