A chemist at a pharmaceutical company is measuring equilibriumconstants for reactions in which drug candidatemolecules bind to a protein involved in cancer. The drugmolecules bind the protein in a 1:1 ratio to form a drug–proteincomplex. The protein concentration in aqueous solutionat 25 °C is 1.50 x 10-6 M. Drug A is introduced into the proteinsolution at an initial concentration of 2.00 x 10-6 M.Drug B is introduced into a separate, identical protein solutionat an initial concentration of 2.00x 10-6 M. At equilibrium,the drug A–protein solution has an A–protein complexconcentration of 1.00 x 10-6 M, and the drug B solutionhas a B–protein complex concentration of 1.40 x 10-6 M.Calculate the Kc value for the A–protein binding reactionand for the B–protein binding reaction. Assuming that thedrug that binds more strongly will be more effective, whichdrug is the better choice for further research?
A chemist at a pharmaceutical company is measuring equilibrium
constants for reactions in which drug candidate
molecules bind to a protein involved in cancer. The drug
molecules bind the protein in a 1:1 ratio to form a drug–protein
complex. The protein concentration in aqueous solution
at 25 °C is 1.50 x 10-6 M. Drug A is introduced into the protein
solution at an initial concentration of 2.00 x 10-6 M.
Drug B is introduced into a separate, identical protein solution
at an initial concentration of 2.00x 10-6 M. At equilibrium,
the drug A–protein solution has an A–protein complex
concentration of 1.00 x 10-6 M, and the drug B solution
has a B–protein complex concentration of 1.40 x 10-6 M.
Calculate the Kc value for the A–protein binding reaction
and for the B–protein binding reaction. Assuming that the
drug that binds more strongly will be more effective, which
drug is the better choice for further research?
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