A 6 month old infant with progressive failure to thrive and milestone regression is being evaluated for an inborn error of metabolism. On examination, hypotonia, apathy, deafness, hepatosplenomegaly and generalised lymphadenopathy are present. Fundus examination shows cherry red spot. A liver biopsy shows foamy hepatocytes loaded with sphingomyelin. Electron microscopy reveals zebra body. What is the diagnosis? please explain.
A 6 month old infant with progressive failure to thrive and milestone regression is being evaluated for an inborn error of metabolism. On examination, hypotonia, apathy, deafness, hepatosplenomegaly and generalised lymphadenopathy are present. Fundus examination shows cherry red spot. A liver biopsy shows foamy hepatocytes loaded with sphingomyelin. Electron microscopy reveals zebra body. What is the diagnosis? please explain.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
I need the answer as soon as possible

Transcribed Image Text:A 6 month old infant with progressive failure
to thrive and milestone regression is being
evaluated for an inborn error of metabolism.
On examination, hypotonia, apathy, deafness,
hepatosplenomegaly and generalised
lymphadenopathy are present. Fundus
examination shows cherry red spot. A liver
biopsy shows foamy hepatocytes loaded
with sphingomyelin. Electron microscopy
reveals zebra body. What is the diagnosis?
please explain.
Expert Solution

This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps

Recommended textbooks for you

Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman

Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY

Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman

Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY

Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning

Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning

Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON