A 54-year-old woman comes to the physician because of painful blisters on the trunk that appeared 3 days ago. She has also had a 2-month history of intermittent, painful lesions in the mouth. Physical examination shows several erosions on the buccal mucosa, lips and multiple flaccid blisters on the trunk. A Skin biopsy of the lesion shows detachment of keratinocytes within the epidermis. Which of the following is the underlying mechanism of the skin condition described? Answers A - E A IgA deposition in the tips of dermal papilla B IgE mediated type I hypersensitivity reaction C IgG autoantibodies against the desmosome D IgG autoantibodies against the hemidesmosome E Uroporphyrinogen decarboxylase deficiency O O O O

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