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A 36-year-old man came to meet a gastroenterologist with a terrible abdominal pain which lasted for several days. During the endoscopic examination, the doctor noticed two ulcers and prominent gastric folds in the stomach. Relevant laboratory test results are as follows: Gastric pH: < 2.0 Fasting gastrin: 1500 pg/mL (normal: < 90 pg/MI) Basal gastric acid output: > 15 mEq/h (normal: < 15 Eq/h) The doctor suspects that the increased stomach acid is a condition of Zollinger-Ellison syndrome (ZES) which is a rare disorder caused by gastrin-producing tumours in the pancreas called gastrinomas. The excess gastrin causes hyperacidity, mucosal disruption/ulcers and proliferation of acid-producing cells or more gastric folds of the stomach (i) How is acid generated in the stomach? Which cells secrete acid? (ii) How is secretion of gastric acid normally regulated? In your answer, indicate why fasting gastrin is used for diagnosing gastrinoma.

A 36-year-old man came to meet a gastroenterologist with a terrible abdominal pain which lasted for several days. During the endoscopic examination, the doctor noticed two ulcers and prominent gastric folds in the stomach. Relevant laboratory test results are as follows: Gastric pH: < 2.0 Fasting gastrin: 1500 pg/mL (normal: < 90 pg/MI) Basal gastric acid output: > 15 mEq/h (normal: < 15 Eq/h) The doctor suspects that the increased stomach acid is a condition of Zollinger-Ellison syndrome (ZES) which is a rare disorder caused by gastrin-producing tumours in the pancreas called gastrinomas. The excess gastrin causes hyperacidity, mucosal disruption/ulcers and proliferation of acid-producing cells or more gastric folds of the stomach (i) How is acid generated in the stomach? Which cells secrete acid? (ii) How is secretion of gastric acid normally regulated? In your answer, indicate why fasting gastrin is used for diagnosing gastrinoma.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A 36-year-old man came to meet a gastroenterologist with a terrible abdominal pain which lasted for several days. During the endoscopic examination, the doctor noticed two ulcers and prominent gastric folds in the stomach. Relevant laboratory test results are as follows: Gastric pH: < 2.0 Fasting gastrin: 1500 pg/mL (normal: < 90 pg/MI) Basal gastric acid output: > 15 mEq/h (normal: < 15 Eq/h) The doctor suspects that the increased stomach acid is a condition of Zollinger-Ellison syndrome (ZES) which is a rare disorder caused by gastrin-producing tumours in the pancreas called gastrinomas. The excess gastrin causes hyperacidity, mucosal disruption/ulcers and proliferation of acid-producing cells or more gastric folds of the stomach (i) How is acid generated in the stomach? Which cells secrete acid? (ii) How is secretion of gastric acid normally regulated? In your answer, indicate why fasting gastrin is used for diagnosing gastrinoma.
Transcribed Image Text:A 36-year-old man came to meet a gastroenterologist with a terrible abdominal pain which lasted for several days. During the endoscopic examination, the doctor noticed two ulcers and prominent gastric folds in the stomach. Relevant laboratory test results are as follows: Gastric pH: < 2.0 Fasting gastrin: 1500 pg/mL (normal: < 90 pg/MI) Basal gastric acid output: > 15 mEq/h (normal: < 15 Eq/h) The doctor suspects that the increased stomach acid is a condition of Zollinger-Ellison syndrome (ZES) which is a rare disorder caused by gastrin-producing tumours in the pancreas called gastrinomas. The excess gastrin causes hyperacidity, mucosal disruption/ulcers and proliferation of acid-producing cells or more gastric folds of the stomach (i) How is acid generated in the stomach? Which cells secrete acid? (ii) How is secretion of gastric acid normally regulated? In your answer, indicate why fasting gastrin is used for diagnosing gastrinoma.
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