Please do this 9. Which of the following statements about trypsin, chymotrypsin, and elastase are true?A. They are serine proteases.B. They are endopeptidases.C. Serine is part of both tetrahedral intermediates in the enzymatic mechanism.D. Acid, base, and nucleophilic catalysis are utilized in the overall mechanism for theseproteases.E. All of the above are true.10. Which of the following statements about enzyme-catalyzed isomerization of glucose-6-phosphate to fructose-6-phosphate is not true?A. The mechanism is totally different from thelaboratory version of the enediol rearrangement.B. The first step is acid- and base-catalyzed ring opening.C. The second step is a base-catalyzed enediol rearrangement.D. The third step is acid- and base-catalyzed conversion of the enediol to a ketone.E. The fourth step is acid- and base-catalyzed ring closure.

Trypsin, Chymotrypsin and Elastase all three are protein digesting enzyme which uses its active site…

Answered: 9. Which of the following statements…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Proteases are one of the main drug targets. Choose the False statement regarding proteases. A. Proteases are enzymes that cleave peptide bonds. B. Water is a reactant in the reaction catalyzed by proteases. C. Proteases, like all enzymes show substrate specificity, meaning they cleave only substate that fit the bonding product. D. Proteases rely on the proton transfer from NADH to the substrate. E. Protease mechanism involves only acid-base catalysis.
5. Which of the following is not a suitable starting compound for gluconeogenesis? A. Lactate B. Pyruvate C. Leucine D. Alanine E. Glycerol 6. What term is used to describe reactions that generate metabolic intermediates of a pathway? A. Amphibolic B. Anaplerotic C. Amphipathic D. Refilling 7. Which of the following statements regarding the regulation of glycogen metabolism is false? A. Glycogen synthase activity is dictated by its phosphorylation status. B. Glycogen phosphorylase is inhibited by ATP. C. Adrenaline stimulates glycogen breakdown. D. Glycogen phosphorylase is activated by AMP and glucose-6-phosphate. E. Glucagon signals that concentrations of blood glucose are low and leads to breakdown of glycogen.
1.Why do you think glutathione occurs in a concentration as high as glucose? 2.Explain why glutathione must be transported from cytosol to mitochondria. 3.Explain why glutathione can confer therapeutic benefit when taken orally.
5. Treatment of the patients with familial hypercholesterolemia by statins (pravastatin, for instants) allows to decrease cholesterol levels in blood up to the normal range. Explain the statin action on the cholesterol metabolism. For that: a) draw the scheme of the cholesterol synthesis, indicate the key enzyme of the pathway; b) name all mechanisms of the key enzyme regulation and statin's action; c) describe the structure of LDL receptor and its function in cholesterol metabolism; d) explain the cause of familial hypercholesterolemia and the symptoms of the disease.
7. An enzyme-catalyzed reaction proceeds by the mechanism below: E+S1ES --2E+P E+A 3 EA EA+S4→ EAS --5→ EA + P E+I6 → EI EAS +17→ EAIS -8 EIS + P A. B. C. E = enzyme, S = substrate, I = inhibitor, P = product and A = activator Rate constants (k's) for the forward reactions are: K1, K2, k3, K4, k5, k6, k7, and k8 Rate constants (k's) for the reverse reactions are: k-1, k-3, K.4, k.6, and k.7 Write the enzyme balance for this mechanism. How many total equations will result from applying the RAPID EQUILIBRIUM ASSUMPTION? Using any concentrations of species in the mechanism and any of the rate constants (k's), write ONE of the equations that would result from applying the QUASI STEADY STATE ASSUMPTION. (ONLY ONE EQUATION; ANY OF THEM ARE FINE)
7. An enzyme-catalyzed reaction proceeds by the mechanism below: B. E+S1→ ES --2E+P E+A 3 EA EA+S4 EAS --5 EA + P E+I 6 EI EAS+I7 → EAIS -8 EIS + P K. macronutrient L. enzyme activator/cofactor M. liposome N. anaerobic process O. aerobic process E = enzyme, S = substrate, I = inhibitor, P = product and A = activator Rate constants (k's) for the forward reactions are: kı, k2, k3, k4, k5, k6, k7, and ks Rate constants (k's) for the reverse reactions are: k-1, k-3, k-4, k-6, and k-7 Write the enzyme balance for this mechanism. 4 How many total equations will result from applying the RAPID EQUILIBRIUM ASSUMPTION? Using any concentrations of species in the mechanism and any of the rate constants (k's), write ONE of the
1. Which of the following statements is/are TRUE for both the concerted and sequential models of allosteric enzymes? a. follows the induced-fit model b. the activator can only bind to the R form c. the inhibitor can only bind to the T form d. the substrate can only bind to the R form 2. Which of the following describes the efficiency of enzymatic catalysis? a. [S] b. KM c. Vmax d. kcat
5. Richner-Hanhart syndrome is associated with a defect in which of the following? A. Fumarylacetoacetate hydrolase B. Tyrosine aminotransferase C. p-hydroxyphenylpyruvate hydroxylase D. Homogentisate oxidase
1. Substrates and reactive groups in an enzyme’s active site must be precisely aligned in order for a productive reaction to occur. Why, then, is some conformational flexibility also a requirement for catalysis? 2. Some plants contain compounds that inhibit serine proteases. It has been hypothesized that these compounds protect the plant from proteolytic enzymes of insects and microorganisms that would damage the plant. Tofu, or bean curd, possesses these compounds. Manufacturers of tofu treat it to eliminate serine protease inhibitors. Why is this treatment necessary?
Proteases belong to the 'lyases' group of enzymes: a. FALSE b. TRUE
Zymogens are NOT enzymatically active, because O A. they are not yet shaped such that essential proximity and orientation catalysis can occur. B. the active site amino acids have been mutated. O C. they have not yet bound the proper cofactor D. they are always smaller than active enzymes.
4. Hexokinase is kinase that catalyzes the phosphorylation of glucose by ATP to glucose-6-P, which can bind toits active site, blocking the access to ATP. Which of the following statements is/are correct regarding the typeof regulation?a) Phosphorylationb) Dephosphorylation.c) Feedback inhibition.d) Repression Explain each of the following option

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