8. You are testing a drug that is an allosteric regulator of PFK-1 and get the following data. Is the drug an allosteric activator or inhibitor? With drug No drug velocity [substrate] Answer: Activator
8. You are testing a drug that is an allosteric regulator of PFK-1 and get the following data. Is the drug an allosteric activator or inhibitor? With drug No drug velocity [substrate] Answer: Activator
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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![8. You are testing a drug that is an allosteric regulator of PFK-1 and get the
following data. Is the drug an allosteric activator or inhibitor?
With drug /
No drug
velocity
[substrate]
Answer: Activator
9. Based on your answer to question 8, how would the flux of glucose metabolism
be affected (which pathway would be activated or inhibited)?
Answer: glycolysis would be inhibited
10. Glucose metabolic flux can be controlled by hormones. What hormone must
have been added to have the following effect on an enzyme in the gluconeogenesis
pathway?
With
Steady-state; no hormone
hormone
velocity
[substrate]
Answer: glucagon](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F6e35c96f-9b3e-46d6-a322-317a3473f2a3%2F680b6f3a-2526-4b0a-868f-71ae398be648%2F2ps3hkf_processed.jpeg&w=3840&q=75)
Transcribed Image Text:8. You are testing a drug that is an allosteric regulator of PFK-1 and get the
following data. Is the drug an allosteric activator or inhibitor?
With drug /
No drug
velocity
[substrate]
Answer: Activator
9. Based on your answer to question 8, how would the flux of glucose metabolism
be affected (which pathway would be activated or inhibited)?
Answer: glycolysis would be inhibited
10. Glucose metabolic flux can be controlled by hormones. What hormone must
have been added to have the following effect on an enzyme in the gluconeogenesis
pathway?
With
Steady-state; no hormone
hormone
velocity
[substrate]
Answer: glucagon
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