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8. You are testing a drug that is an allosteric regulator of PFK-1 and get the following data. Is the drug an allosteric activator or inhibitor? With drug No drug velocity [substrate] Answer: Activator

8. You are testing a drug that is an allosteric regulator of PFK-1 and get the following data. Is the drug an allosteric activator or inhibitor? With drug No drug velocity [substrate] Answer: Activator

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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8. You are testing a drug that is an allosteric regulator of PFK-1 and get the following data. Is the drug an allosteric activator or inhibitor? With drug / No drug velocity [substrate] Answer: Activator 9. Based on your answer to question 8, how would the flux of glucose metabolism be affected (which pathway would be activated or inhibited)? Answer: glycolysis would be inhibited 10. Glucose metabolic flux can be controlled by hormones. What hormone must have been added to have the following effect on an enzyme in the gluconeogenesis pathway? With Steady-state; no hormone hormone velocity [substrate] Answer: glucagon
Transcribed Image Text:8. You are testing a drug that is an allosteric regulator of PFK-1 and get the following data. Is the drug an allosteric activator or inhibitor? With drug / No drug velocity [substrate] Answer: Activator 9. Based on your answer to question 8, how would the flux of glucose metabolism be affected (which pathway would be activated or inhibited)? Answer: glycolysis would be inhibited 10. Glucose metabolic flux can be controlled by hormones. What hormone must have been added to have the following effect on an enzyme in the gluconeogenesis pathway? With Steady-state; no hormone hormone velocity [substrate] Answer: glucagon
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