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7. kynureninase with an inhibitor, 3-hydroxyhippurate, bound in the active site. The structure is shown below in crossed-eye stereo, with the inhibitor shown in the ball and stick model. Indicate the forces involved in the binding of this inhibitor. Recently in my laboratory we determined the structure of human

7. kynureninase with an inhibitor, 3-hydroxyhippurate, bound in the active site. The structure is shown below in crossed-eye stereo, with the inhibitor shown in the ball and stick model. Indicate the forces involved in the binding of this inhibitor. Recently in my laboratory we determined the structure of human

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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7. Recently in my laboratory we determined the structure of human kynureninase with an inhibitor, 3-hydroxyhippurate, bound in the active site. The structure is shown below in crossed-eye stereo, with the inhibitor shown in the ball and stick model. Indicate the forces involved in the binding of this inhibitor. Trp-305* Trр-305 Phe-165 Phe-306* Phe-165 Phe-306* PLP PLP Phe-314 Asn-333* Phe-314* Asn-333* His-253 669 His-253 669 Tyr-s 3-ННА Tyr5 3-ННА Ile-110* Ile-110* Arg-434 His-102* Arg-434 His-102* Ser-75 Ser-75 Lys-276 Lys-276
Transcribed Image Text:7. Recently in my laboratory we determined the structure of human kynureninase with an inhibitor, 3-hydroxyhippurate, bound in the active site. The structure is shown below in crossed-eye stereo, with the inhibitor shown in the ball and stick model. Indicate the forces involved in the binding of this inhibitor. Trp-305* Trр-305 Phe-165 Phe-306* Phe-165 Phe-306* PLP PLP Phe-314 Asn-333* Phe-314* Asn-333* His-253 669 His-253 669 Tyr-s 3-ННА Tyr5 3-ННА Ile-110* Ile-110* Arg-434 His-102* Arg-434 His-102* Ser-75 Ser-75 Lys-276 Lys-276
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