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6. Emtriva acts as a nucleoside analog reverse-transcriptase inhibitor (NRTI). Here is a drawing of Emtriva. A nucleoside is a molecule with a sugar and a base. A nucleotide is a molecule with a sugar, a base, and phosphate group(s). Scientists do not draw every atom and bond because they assume you know that there is a carbon (C) at every intersection of the lines that has no atom indicated, like at the 2' position in the molecule below. Also, we hate to write out all of the hydrogens. Count the number of bonds expected for each atom in the structure; if the number of bonds drawn is less than expected, that means that there is actually a hydrogen bonded there. A. Draw on the molecule below to indicate the C and H atoms and bonds not shown. 12 19 32 (Hints: ¹2C ¹60 ¹4. S',H) 6 НО. 16 S N NH₂ N F B. Emtriva is called a "chain terminator" because it can be incorporated in a nucleic acid chain but it terminates the chain by blocking addition of any additional nucleotides. Circle the part of Emtriva in Question that would block polymerization.

6. Emtriva acts as a nucleoside analog reverse-transcriptase inhibitor (NRTI). Here is a drawing of Emtriva. A nucleoside is a molecule with a sugar and a base. A nucleotide is a molecule with a sugar, a base, and phosphate group(s). Scientists do not draw every atom and bond because they assume you know that there is a carbon (C) at every intersection of the lines that has no atom indicated, like at the 2' position in the molecule below. Also, we hate to write out all of the hydrogens. Count the number of bonds expected for each atom in the structure; if the number of bonds drawn is less than expected, that means that there is actually a hydrogen bonded there. A. Draw on the molecule below to indicate the C and H atoms and bonds not shown. 12 19 32 (Hints: ¹2C ¹60 ¹4. S',H) 6 НО. 16 S N NH₂ N F B. Emtriva is called a "chain terminator" because it can be incorporated in a nucleic acid chain but it terminates the chain by blocking addition of any additional nucleotides. Circle the part of Emtriva in Question that would block polymerization.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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**6. Emtriva as a Nucleoside Analog Reverse-Transcriptase Inhibitor (NRTI)** **Overview:** Emtriva (Emtricitabine) is a nucleoside analog reverse-transcriptase inhibitor (NRTI). Here is a drawing of Emtriva. A nucleoside is a molecule with a sugar and a base. A nucleotide is a molecule with a sugar, a base, and phosphate group(s). Scientists do not depict every atom and bond because they assume you understand that a carbon (C) is present at every intersection of lines without a specified atom. For example, at the 2’ position in the molecule below. Additionally, all hydrogen atoms are not explicitly written. Count the number of bonds expected for each atom in the structure; if the number of bonds drawn is less than expected, there is a hydrogen bonded there. **Instructions:** **A. Draw the C and H atoms and bonds not shown in the molecule below.** *(Hints: \( \prescript{12}{}{\text{C}}, \prescript{16}{}{\text{O}}, \prescript{14}{}{\text{N}}, \prescript{19}{}{\text{F}}, \prescript{32}{}{\text{S}}, \prescript{1}{}{\text{H}} \))* **Molecular Diagram Explanation:** - **Chemical Structure:** The diagram features a complex chemical structure of Emtriva. The central structure includes a 5-membered ring fused with a 6-membered ring. - **Atoms Labeled:** The atoms labeled include Nitrogen (N), Oxygen (O), Fluorine (F), and Sulfur (S). Hydrogens are implied but not shown directly. - **Functional Groups:** Features amine (NH2), alcohol (OH), and other unspecified groups. **B. Chain Termination Property:** Emtriva is termed as a “chain terminator” because it can be incorporated into a nucleic acid chain but stops the chain by preventing the addition of any further nucleotides. **Circle the part of Emtriva that would block polymerization.**
Transcribed Image Text:**6. Emtriva as a Nucleoside Analog Reverse-Transcriptase Inhibitor (NRTI)** **Overview:** Emtriva (Emtricitabine) is a nucleoside analog reverse-transcriptase inhibitor (NRTI). Here is a drawing of Emtriva. A nucleoside is a molecule with a sugar and a base. A nucleotide is a molecule with a sugar, a base, and phosphate group(s). Scientists do not depict every atom and bond because they assume you understand that a carbon (C) is present at every intersection of lines without a specified atom. For example, at the 2’ position in the molecule below. Additionally, all hydrogen atoms are not explicitly written. Count the number of bonds expected for each atom in the structure; if the number of bonds drawn is less than expected, there is a hydrogen bonded there. **Instructions:** **A. Draw the C and H atoms and bonds not shown in the molecule below.** *(Hints: \( \prescript{12}{}{\text{C}}, \prescript{16}{}{\text{O}}, \prescript{14}{}{\text{N}}, \prescript{19}{}{\text{F}}, \prescript{32}{}{\text{S}}, \prescript{1}{}{\text{H}} \))* **Molecular Diagram Explanation:** - **Chemical Structure:** The diagram features a complex chemical structure of Emtriva. The central structure includes a 5-membered ring fused with a 6-membered ring. - **Atoms Labeled:** The atoms labeled include Nitrogen (N), Oxygen (O), Fluorine (F), and Sulfur (S). Hydrogens are implied but not shown directly. - **Functional Groups:** Features amine (NH2), alcohol (OH), and other unspecified groups. **B. Chain Termination Property:** Emtriva is termed as a “chain terminator” because it can be incorporated into a nucleic acid chain but stops the chain by preventing the addition of any further nucleotides. **Circle the part of Emtriva that would block polymerization.**
Expert Solution
Step 1: Bond line structures

Bond line structures are a way of representing chemical structure. There are few considerations while drawing bond line structures:

  1. Carbon atoms are not labelled
  2. Hydrogen atoms are not shown except when stereochemistry is depicted.

Heteroatoms are represented in between the bond lines. 

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