6 A drug that displays dose-dependent pharmacokinetics will be eliminated by first-order kinetics if: A. Administered orally B. A first-pass effect occurs C. The plasma drug concentration is relatively low 2 D. The plasma drug concentration is relatively high E. B&D only 27. Phenytoin displays dose dependent pharmacokinetics because of saturable: A. Gl absorption B Protein binding C. Renal elimination D. Metabolism E. Biliary excretion 28. The ratio of daily dose to steady-state (Le., DD/C.) has the same value as: A. Elimination half-life 3 B Total clearance C. Area under the curve D. Apparent volume of distribution E. Vna 29. For a drug that displays dose-dependent pharmacokinetics, the daily dose should never exceed: A. Plasma drug concentration B. Vma C. K D. Dosing interval E. 1000 mg

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