Which of the following acid-base systems is NOT suitable to prepare a buffer with a pH 7.4? MTS Tris (tris(hydroxymethyl)aminomethane): pK₁ = 8.0 Phosphate: pKal = 2.16 pKa2 = 7.21 pK₁3 = 12.32 Leucine: pKal= 2.328, pKa2=9.744 HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid): pKal = 3.0, pka2 = 7.5
Which of the following acid-base systems is NOT suitable to prepare a buffer with a pH 7.4? MTS Tris (tris(hydroxymethyl)aminomethane): pK₁ = 8.0 Phosphate: pKal = 2.16 pKa2 = 7.21 pK₁3 = 12.32 Leucine: pKal= 2.328, pKa2=9.744 HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid): pKal = 3.0, pka2 = 7.5
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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
Transcribed Image Text:5. Which of the following acid-base systems is NOT suitable to prepare a buffer with a pH 7.4?
MTS88,0
MACELI
A. Tris (tris(hydroxymethyl)aminomethane): pKa = 8.0
3. Phosphate: pKal = 2.16 pKa2 = 7.21 pka3 = 12.32
C. Leucine: pKal= 2.328, pKa2=9.744
D. HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid): pKal = 3.0, pKa2 = 7.5
Expert Solution
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Step 1
The main objective while selecting the acid-base system is to choose the buffer whose pKa values are closest to the target pH.
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