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5. Patients with palmoplantar keratoderma (PPK) have yellowish thickening of the skin on their hands and feet. Here is the pedigree of a family that has PPK. 2 Beneath the pedigree are two gels with results of PCR amplification of two STRS (short tandem repeats, similar to VNTRS). D12S3 is located near the keratin 1 gene, and D17S5 is located near the keratin 9 gene. There are 5 alleles of D12S3 (A-E) and 4 alleles of D1755 (A-D). -1 1-2 |l-1 I-2 |I-3, Keratin 1 D1283 A. B. C. D. E. In this family, do individuals with PPK likely have a mutation in keratin 1, keratin 9, or both? Explain, describing the data that 1 1-2 ||-1 |-2 I1-3 D17S5 Keratin 9 A. B. supports your conclusion. C. D. What follow-up experiments/data would you like to verify your conclusions? Explain.

5. Patients with palmoplantar keratoderma (PPK) have yellowish thickening of the skin on their hands and feet. Here is the pedigree of a family that has PPK. 2 Beneath the pedigree are two gels with results of PCR amplification of two STRS (short tandem repeats, similar to VNTRS). D12S3 is located near the keratin 1 gene, and D17S5 is located near the keratin 9 gene. There are 5 alleles of D12S3 (A-E) and 4 alleles of D1755 (A-D). -1 1-2 |l-1 I-2 |I-3, Keratin 1 D1283 A. B. C. D. E. In this family, do individuals with PPK likely have a mutation in keratin 1, keratin 9, or both? Explain, describing the data that 1 1-2 ||-1 |-2 I1-3 D17S5 Keratin 9 A. B. supports your conclusion. C. D. What follow-up experiments/data would you like to verify your conclusions? Explain.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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5. Patients with palmoplantar keratoderma (PPK) have yellowish thickening of the skin on their hands and feet. Here is the pedigree of a family that has PPK. I. Beneath the pedigree are two gels with results of PCR amplification of two STRS (short tandem repeats, similar to VNTRS). D12S3 is located near the keratin 1 gene, and D17S5 is located near the keratin 9 gene. There are 5 alleles of D12S3 (A-E) and 4 alleles of D175 (A-D). D12S3 |-1 1-2 ||-1 |l-2 I-3 Keratin 1 O D O O O А. В. C. D E. In this family, do individuals with PPK likely have a mutation in keratin 1, keratin 9, or both? Explain, describing the data that |-1. 1-2 ||-1 ||-2 ||-3 D17S5 Keratin 9 A. B. supports your conclusion. C. D. What follow-up experiments/data would you like to verify your conclusions? Explain.
Transcribed Image Text:5. Patients with palmoplantar keratoderma (PPK) have yellowish thickening of the skin on their hands and feet. Here is the pedigree of a family that has PPK. I. Beneath the pedigree are two gels with results of PCR amplification of two STRS (short tandem repeats, similar to VNTRS). D12S3 is located near the keratin 1 gene, and D17S5 is located near the keratin 9 gene. There are 5 alleles of D12S3 (A-E) and 4 alleles of D175 (A-D). D12S3 |-1 1-2 ||-1 |l-2 I-3 Keratin 1 O D O O O А. В. C. D E. In this family, do individuals with PPK likely have a mutation in keratin 1, keratin 9, or both? Explain, describing the data that |-1. 1-2 ||-1 ||-2 ||-3 D17S5 Keratin 9 A. B. supports your conclusion. C. D. What follow-up experiments/data would you like to verify your conclusions? Explain.
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