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5. A metabolic pathway with the end product "Blue fish" is shown below. The enzymes that catalyze each step are shown in italics above each arrow. The committed step is the conversion of One Fish to Two Fish by Seuss1. a. Briefly explain what the “committed step" of a pathway is. Also explain why it makes sense for Seuss1 to catalyze the committed step, and why this step is most likely to be allosterically controlled. Seuss1 Seuss2 Seuss3 One fish → Two fish → Red fish → Blue fish

5. A metabolic pathway with the end product "Blue fish" is shown below. The enzymes that catalyze each step are shown in italics above each arrow. The committed step is the conversion of One Fish to Two Fish by Seuss1. a. Briefly explain what the “committed step" of a pathway is. Also explain why it makes sense for Seuss1 to catalyze the committed step, and why this step is most likely to be allosterically controlled. Seuss1 Seuss2 Seuss3 One fish → Two fish → Red fish → Blue fish

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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5. A metabolic pathway with the end product “Blue fish" is shown below. The enzymes that catalyze each step are shown in italics above each arrow. The committed step is the conversion of One Fish to Two Fish by Seuss1. a. Briefly explain what the “committed step" of a pathway is. Also explain why it makes sense for Seuss1 to catalyze the committed step, and why this step is most likely to be allosterically controlled. Seuss1 Seuss2 Seuss3 One fish > Two fish → Red fish → Blue fish b. Blue Fish acts as an allosteric ligand to control the activity of Seuss1. The binding sites for the substrate of Seuss1 (One Fish) are circled. Use an arrow to show where the allosteric ligand Blue Fish might bind. Explain your choice. c. The normal activity of Seussl is shown below as the solid line, "Control." (The x-axis, S, is the concentration of the substrate Blue Fish.) Which of the dotted lines do you think shows the activity of Seuss1 in the presence of high Control concentrations of Blue Fish? Does Blue Fish primarily change Vmax or Km? (a)
Transcribed Image Text:5. A metabolic pathway with the end product “Blue fish" is shown below. The enzymes that catalyze each step are shown in italics above each arrow. The committed step is the conversion of One Fish to Two Fish by Seuss1. a. Briefly explain what the “committed step" of a pathway is. Also explain why it makes sense for Seuss1 to catalyze the committed step, and why this step is most likely to be allosterically controlled. Seuss1 Seuss2 Seuss3 One fish > Two fish → Red fish → Blue fish b. Blue Fish acts as an allosteric ligand to control the activity of Seuss1. The binding sites for the substrate of Seuss1 (One Fish) are circled. Use an arrow to show where the allosteric ligand Blue Fish might bind. Explain your choice. c. The normal activity of Seussl is shown below as the solid line, "Control." (The x-axis, S, is the concentration of the substrate Blue Fish.) Which of the dotted lines do you think shows the activity of Seuss1 in the presence of high Control concentrations of Blue Fish? Does Blue Fish primarily change Vmax or Km? (a)
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