5) Under specific conditions, hemoglobin dissociates into its four subunits. The isolated a subunit binds oxygen, but the O2-saturation curve is hyperbolic rather than sigmoidal. In addition, the binding of oxygen to the isolated a subunit is not affected by pH, or the allosteric regulator BPG. Use your knowledge about hemoglobin and the information provided in this question to answer: a. Draw the expected O₂ binding curves for tetrameric hemoglobin and for the isolated a subunit (draw them on the same axes). How can you explain their different behavior? b. Draw the expected Hill plot for tetrameric hemoglobin and for the isolated a subunit. c. What Hill coefficient (n) will you expect for tetrameric hemoglobin and for the isolated a subunit? d. How would you use each of these graphs to determine dissociation constants for the binding of oxygen to tetrameric hemoglobin and to the isolated a subunit? e. Why is the isolated a subunit unaffected by pH or BPG?

5) Under specific conditions, hemoglobin dissociates into its four subunits. The isolated a subunit binds oxygen, but the O2-saturation curve is hyperbolic rather than sigmoidal. In addition, the binding of oxygen to the isolated a subunit is not affected by pH, or the allosteric regulator BPG. Use your knowledge about hemoglobin and the information provided in this question to answer: a. Draw the expected O₂ binding curves for tetrameric hemoglobin and for the isolated a subunit (draw them on the same axes). How can you explain their different behavior? b. Draw the expected Hill plot for tetrameric hemoglobin and for the isolated a subunit. c. What Hill coefficient (n) will you expect for tetrameric hemoglobin and for the isolated a subunit? d. How would you use each of these graphs to determine dissociation constants for the binding of oxygen to tetrameric hemoglobin and to the isolated a subunit? e. Why is the isolated a subunit unaffected by pH or BPG?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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