5' 3' • TGT • • ACA • DNA 3' 5' IT TGT АСА TG C АCG TGG АСС TIT TGA АСТ Mutation U ĠŮ UGÅ Transcribed codon Cysteine Cysteine Tryptophan Stop codon Amino acid translated Wild type Silent Missense Nonsense Outcome mutation mutation mutation FIGURE 8.3 Potential Outcomes of Base Substitutions Outcomes include silent, missense, and nonsense mutations. in

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Which of these outcomes is most likely to result in a leaky mutation?

5'
3'
• TGT •
• ACA •
DNA
3'
5'
IT
TGT
АСА
TG C
АCG
TGG
АСС
TIT
TGA
АСТ
Mutation
U ĠŮ
UGÅ
Transcribed codon
Cysteine Cysteine Tryptophan Stop codon Amino acid translated
Wild type Silent
Missense Nonsense Outcome
mutation
mutation mutation
FIGURE 8.3 Potential Outcomes of Base Substitutions
Outcomes include silent, missense, and nonsense mutations.
in
Transcribed Image Text:5' 3' • TGT • • ACA • DNA 3' 5' IT TGT АСА TG C АCG TGG АСС TIT TGA АСТ Mutation U ĠŮ UGÅ Transcribed codon Cysteine Cysteine Tryptophan Stop codon Amino acid translated Wild type Silent Missense Nonsense Outcome mutation mutation mutation FIGURE 8.3 Potential Outcomes of Base Substitutions Outcomes include silent, missense, and nonsense mutations. in
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