5° 3' 5' C:G 3' C:G A:T T:A A:T T:A Depurination Apurinic site C:G G:C G:C 3° 3" (a) Depurination 5' 3' C:G A:T T:A 3" C:G G:C A:T T:A DNA replication 3" :C: G:C 3" C:G 3" A:T T:A X could be A, T, G, or C G:C (b) Replication over an apurinic site FIGURE 19.7 Spontaneous depurination. (a) The bond be- tween guanine and deoxyribose is broken, thereby releasing the base. This leaves an apurinic site in the DNA. (b) If an apurinic site remains in the DNA as it is being replicated, any of the four nucleotides can be added to the newly made strand.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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When DNA replication occurs over an apurinic site, what is the probability that a mutation will occur?

5°
3'
5'
C:G
3'
C:G
A:T
T:A
A:T
T:A
Depurination
Apurinic site
C:G
G:C
G:C
3°
3"
(a) Depurination
5'
3'
C:G
A:T
T:A
3"
C:G
G:C
A:T
T:A
DNA replication
3"
:C:
G:C
3"
C:G
3"
A:T
T:A
X could be
A, T, G, or C
G:C
(b) Replication over an apurinic site
FIGURE 19.7 Spontaneous depurination. (a) The bond be-
tween guanine and deoxyribose is broken, thereby releasing the base.
This leaves an apurinic site in the DNA. (b) If an apurinic site remains
in the DNA as it is being replicated, any of the four nucleotides can be
added to the newly made strand.
Transcribed Image Text:5° 3' 5' C:G 3' C:G A:T T:A A:T T:A Depurination Apurinic site C:G G:C G:C 3° 3" (a) Depurination 5' 3' C:G A:T T:A 3" C:G G:C A:T T:A DNA replication 3" :C: G:C 3" C:G 3" A:T T:A X could be A, T, G, or C G:C (b) Replication over an apurinic site FIGURE 19.7 Spontaneous depurination. (a) The bond be- tween guanine and deoxyribose is broken, thereby releasing the base. This leaves an apurinic site in the DNA. (b) If an apurinic site remains in the DNA as it is being replicated, any of the four nucleotides can be added to the newly made strand.
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