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4. Which one of the compounds below is the major product formed by the reaction sequence shown here? OH A NH₂ OH H3C CH3 OH NH₂ HO Kex X NH₂ B E C acetone NH₂ + CH₂CH₂NO₂ nitroethane OH D NaOH NH₂ H₂, Ni ?

4. Which one of the compounds below is the major product formed by the reaction sequence shown here? OH A NH₂ OH H3C CH3 OH NH₂ HO Kex X NH₂ B E C acetone NH₂ + CH₂CH₂NO₂ nitroethane OH D NaOH NH₂ H₂, Ni ?

Chemistry
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Have an aldol reaction sequence here for practice problems -- any explanation of the reaction steps and solution would be greatly appreciated.  Thanks!

**Question 4:** Which one of the compounds below is the major product formed by the reaction sequence shown here? The reaction involves acetone (C₃H₆O) and nitroethane (C₂H₅NO₂), with reagents sodium hydroxide (NaOH), hydrogen gas (H₂), and nickel (Ni) to determine the major product. **Compounds:** - **A:** A structure featuring a tertiary alcohol and an amine group on a three-carbon chain. - **B:** A structure with a tertiary alcohol and an amine group on a four-carbon chain. - **C:** A structure with a secondary alcohol and an amine group on a three-carbon chain. - **D:** A structure with a primary alcohol and an amine group on a four-carbon chain. - **E:** A structure with a tertiary alcohol and an amine group on a three-carbon chain differently arranged compared to A. **Explanation of Reaction and Options:** The reaction involves a nitroalkane (nitroethane) reacting with a ketone (acetone) in the presence of base (NaOH), followed by hydrogenation over nickel. This indicates a possible nitroaldol reaction followed by reduction, leading to the formation of an alcohol and an amine group on a carbon chain. In diagram explanation: - **Acetone** appears as a carbonyl group flanked by two methyl groups. - **Nitroethane** is shown with a nitro group (NO₂) attached to an ethyl chain. - The reaction is catalyzed with **NaOH** and hydrogen over **Ni**, typically facilitating reduction steps. Select the most appropriate compound based on standard organic synthesis and reaction outcomes.
Transcribed Image Text:**Question 4:** Which one of the compounds below is the major product formed by the reaction sequence shown here? The reaction involves acetone (C₃H₆O) and nitroethane (C₂H₅NO₂), with reagents sodium hydroxide (NaOH), hydrogen gas (H₂), and nickel (Ni) to determine the major product. **Compounds:** - **A:** A structure featuring a tertiary alcohol and an amine group on a three-carbon chain. - **B:** A structure with a tertiary alcohol and an amine group on a four-carbon chain. - **C:** A structure with a secondary alcohol and an amine group on a three-carbon chain. - **D:** A structure with a primary alcohol and an amine group on a four-carbon chain. - **E:** A structure with a tertiary alcohol and an amine group on a three-carbon chain differently arranged compared to A. **Explanation of Reaction and Options:** The reaction involves a nitroalkane (nitroethane) reacting with a ketone (acetone) in the presence of base (NaOH), followed by hydrogenation over nickel. This indicates a possible nitroaldol reaction followed by reduction, leading to the formation of an alcohol and an amine group on a carbon chain. In diagram explanation: - **Acetone** appears as a carbonyl group flanked by two methyl groups. - **Nitroethane** is shown with a nitro group (NO₂) attached to an ethyl chain. - The reaction is catalyzed with **NaOH** and hydrogen over **Ni**, typically facilitating reduction steps. Select the most appropriate compound based on standard organic synthesis and reaction outcomes.
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