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4. Tris(hydroxymethyl)aminomethane [(HOCH2);CNH2–Tris, or THAM] is a weak base frequently used to prepare buffers in biochemistry. Its Kp is 1.2 × 10 6 and pKp is 5.92. The corresponding pKa is 8.08, which is near the pH of the physiological buffers, and so it exhibits good buffering capacity at physiological pH. What weight of THAM must be taken with 100 mL of 0.50 M HCl to prepare 1 L of a pH 7.40 buffer?

4. Tris(hydroxymethyl)aminomethane [(HOCH2);CNH2–Tris, or THAM] is a weak base frequently used to prepare buffers in biochemistry. Its Kp is 1.2 × 10 6 and pKp is 5.92. The corresponding pKa is 8.08, which is near the pH of the physiological buffers, and so it exhibits good buffering capacity at physiological pH. What weight of THAM must be taken with 100 mL of 0.50 M HCl to prepare 1 L of a pH 7.40 buffer?

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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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4. Tris(hydroxymethyl)aminomethane [(HOCH2)3CNH2-Tris, or THAM] is a weak base frequently used to prepare buffers in biochemistry. Its Kp is 1.2 x 10 6 and pKp is 5.92. The corresponding pKa is 8.08, which is near the pH of the physiological buffers, and so it exhibits good buffering capacity at physiological pH. What weight of THAM must be taken with 100 mL of 0.50 M HCl to prepare 1 L of a pH 7.40 buffer? 5. Calculate the pH of a solution that is 0.200 M in NH3 and 0.300 M in NH4CI. Calculate the pH change that takes place when a 100-mL portion of (A) 0.0500 M NaOH and (B) 0.0500 M HCl is added to 400 mL of the buffer solution. Kb = 1.75 x 10-5
Transcribed Image Text:4. Tris(hydroxymethyl)aminomethane [(HOCH2)3CNH2-Tris, or THAM] is a weak base frequently used to prepare buffers in biochemistry. Its Kp is 1.2 x 10 6 and pKp is 5.92. The corresponding pKa is 8.08, which is near the pH of the physiological buffers, and so it exhibits good buffering capacity at physiological pH. What weight of THAM must be taken with 100 mL of 0.50 M HCl to prepare 1 L of a pH 7.40 buffer? 5. Calculate the pH of a solution that is 0.200 M in NH3 and 0.300 M in NH4CI. Calculate the pH change that takes place when a 100-mL portion of (A) 0.0500 M NaOH and (B) 0.0500 M HCl is added to 400 mL of the buffer solution. Kb = 1.75 x 10-5
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