4. Histidine, one of the 20 amino acids, contains an imidazole functional group with a pKa of 6.0. This imidazole can either be protonated, in which case the net charge of the molecule is +1, or deprotonated, making histidine neutral. a. Calculate the ratio of neutral histidine to +1 histidine at pH = 6.9. HN- N₁ d. What is the pH when +1 histidine is present at 19%? b. What is the percent of neutral histidine (uncharged/deptronated) at pH = 7? c. What is the pH when +1 histidine: neutral histidine is 1:4? H NH₂ COOH e. Histidine has 2other functional groups that can be protonated/deprotonated. If histidine's pka's are 2.5, 6.0, 9.0, what is the net charge of histidine at pH 9.0?
4. Histidine, one of the 20 amino acids, contains an imidazole functional group with a pKa of 6.0. This imidazole can either be protonated, in which case the net charge of the molecule is +1, or deprotonated, making histidine neutral. a. Calculate the ratio of neutral histidine to +1 histidine at pH = 6.9. HN- N₁ d. What is the pH when +1 histidine is present at 19%? b. What is the percent of neutral histidine (uncharged/deptronated) at pH = 7? c. What is the pH when +1 histidine: neutral histidine is 1:4? H NH₂ COOH e. Histidine has 2other functional groups that can be protonated/deprotonated. If histidine's pka's are 2.5, 6.0, 9.0, what is the net charge of histidine at pH 9.0?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
4a
Transcribed Image Text:Biochemistry
Chem 348
4. Histidine, one of the 20 amino acids, contains an
imidazole functional group with a pKa of 6.0. This
imidazole can either be protonated, in which case the net
charge of the molecule is +1, or deprotonated, making
histidine neutral.
a. Calculate the ratio of neutral histidine to +1 histidine at pH = 6.9.
HN
Slade
Review Questions
c. What is the pH when +1 histidine: neutral histidine is 1:4?
d. What is the pH when +1 histidine is present at 19%?
b. What is the percent of neutral histidine (uncharged/deptronated) at pH = 7?
H
NH₂
COOH
e. Histidine has 2other functional groups that can be protonated/deprotonated. If
histidine's pka's are 2.5, 6.0, 9.0, what is the net charge of histidine at pH 9.0?
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