4. Ciprofloxacin is a quinolone antibiotic that functions by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. Its chemical structure is shown below: Identify the ionizable groups that have pKa values of 6.1 and 8.6. Draw the structures of ciprofloxacin that predominate in the acidic environment of the stomach (pH ~ 2) and in the near neutral environment of the bloodstream (pH ~ 7.4).
4. Ciprofloxacin is a quinolone antibiotic that functions by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. Its chemical structure is shown below: Identify the ionizable groups that have pKa values of 6.1 and 8.6. Draw the structures of ciprofloxacin that predominate in the acidic environment of the stomach (pH ~ 2) and in the near neutral environment of the bloodstream (pH ~ 7.4).
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![4. Ciprofloxacin is a quinolone antibiotic that functions by inhibiting the bacterial enzymes DNA gyrase
and topoisomerase IV. Its chemical structure is shown below:
Identify the ionizable groups that have pK, values of 6.1 and 8.6. Draw the structures of ciprofloxacin
that predominate in the acidic environment of the stomach (pH ~ 2) and in the near neutral environment
of the bloodstream (pH ~ 7.4).](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F12c101bf-45a6-410c-bd66-a92761de4b15%2Fb61e76ba-6148-4927-a332-03dbbe8872a4%2Fsoxoxle_processed.png&w=3840&q=75)
Transcribed Image Text:4. Ciprofloxacin is a quinolone antibiotic that functions by inhibiting the bacterial enzymes DNA gyrase
and topoisomerase IV. Its chemical structure is shown below:
Identify the ionizable groups that have pK, values of 6.1 and 8.6. Draw the structures of ciprofloxacin
that predominate in the acidic environment of the stomach (pH ~ 2) and in the near neutral environment
of the bloodstream (pH ~ 7.4).
![Question 4:-ts cheroical atou ture is asbown belouI-
HN
N.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F12c101bf-45a6-410c-bd66-a92761de4b15%2Fb61e76ba-6148-4927-a332-03dbbe8872a4%2F08nngbg_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Question 4:-ts cheroical atou ture is asbown belouI-
HN
N.
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