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31. What percent of the peptide Arg-Pro are net positively charged at pH 9.0? The table below gives the pka's of the ionizable groups on the free amino acids. Free amino acid Arginine Proline 1.8 2.0 pKa of alpha- carboxyl group A. 10% B. 30% C. 50% D. 70% E. 90% F. Need more information pKa of alpha-amino pKa of side chain group 9.0 10.6 12.5 none 32. The ionic interactions within a protein molecule are A. Mostly contributed by the side chains of constituent amino acids B. Determined by the contribution from the alpha-carboxyl group, alpha-amino group and side chain of every amino acid in the protein C. Contributed by only the N-terminal and C-terminal residues D. Independent of the amino acid composition and depend only on pH

31. What percent of the peptide Arg-Pro are net positively charged at pH 9.0? The table below gives the pka's of the ionizable groups on the free amino acids. Free amino acid Arginine Proline 1.8 2.0 pKa of alpha- carboxyl group A. 10% B. 30% C. 50% D. 70% E. 90% F. Need more information pKa of alpha-amino pKa of side chain group 9.0 10.6 12.5 none 32. The ionic interactions within a protein molecule are A. Mostly contributed by the side chains of constituent amino acids B. Determined by the contribution from the alpha-carboxyl group, alpha-amino group and side chain of every amino acid in the protein C. Contributed by only the N-terminal and C-terminal residues D. Independent of the amino acid composition and depend only on pH

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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### Question 31 **What percent of the peptide Arg-Pro are net positively charged at pH 9.0?** The table below gives the pKa's of the ionizable groups on the free amino acids. | **Free amino acid** | **pKa of alpha-carboxyl group** | **pKa of alpha-amino group** | **pKa of side chain** | |-----------------------|-----------------------------------|-----------------------------------|------------------------| | Arginine | 1.8 | 9.0 | 12.5 | | Proline | 2.0 | 10.6 | None | Select one: - A. 10% - B. 30% - C. 50% - D. 70% - E. 90% - F. Need more information --- ### Question 32 **The ionic interactions within a protein molecule are ________.** Select one: - A. Mostly contributed by the side chains of constituent amino acids - B. Determined by the contribution from the alpha-carboxyl group, alpha-amino group and side chain of every amino acid in the protein - C. Contributed by only the N-terminal and C-terminal residues - D. Independent of amino acid composition and depend only on pH --- ### Explanation of the Table The table provided includes pKa values for the alpha-carboxyl group, alpha-amino group, and the side chain of the amino acids Arginine and Proline. pKa values are crucial for understanding the ionization states of amino acid residues in different pH environments. - **For Arginine:** - pKa of alpha-carboxyl group: 1.8 - pKa of alpha-amino group: 9.0 - pKa of side chain: 12.5 - **For Proline:** - pKa of alpha-carboxyl group: 2.0 - pKa of alpha-amino group: 10.6 - pKa of side chain: None By comparing the pH of the environment (9.0) to the pKa values, one can determine which groups are ionized and thus influence the overall charge of the peptide.
Transcribed Image Text:### Question 31 **What percent of the peptide Arg-Pro are net positively charged at pH 9.0?** The table below gives the pKa's of the ionizable groups on the free amino acids. | **Free amino acid** | **pKa of alpha-carboxyl group** | **pKa of alpha-amino group** | **pKa of side chain** | |-----------------------|-----------------------------------|-----------------------------------|------------------------| | Arginine | 1.8 | 9.0 | 12.5 | | Proline | 2.0 | 10.6 | None | Select one: - A. 10% - B. 30% - C. 50% - D. 70% - E. 90% - F. Need more information --- ### Question 32 **The ionic interactions within a protein molecule are ________.** Select one: - A. Mostly contributed by the side chains of constituent amino acids - B. Determined by the contribution from the alpha-carboxyl group, alpha-amino group and side chain of every amino acid in the protein - C. Contributed by only the N-terminal and C-terminal residues - D. Independent of amino acid composition and depend only on pH --- ### Explanation of the Table The table provided includes pKa values for the alpha-carboxyl group, alpha-amino group, and the side chain of the amino acids Arginine and Proline. pKa values are crucial for understanding the ionization states of amino acid residues in different pH environments. - **For Arginine:** - pKa of alpha-carboxyl group: 1.8 - pKa of alpha-amino group: 9.0 - pKa of side chain: 12.5 - **For Proline:** - pKa of alpha-carboxyl group: 2.0 - pKa of alpha-amino group: 10.6 - pKa of side chain: None By comparing the pH of the environment (9.0) to the pKa values, one can determine which groups are ionized and thus influence the overall charge of the peptide.
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