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- Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the phenotype of this individual be?Consider the pedigree of a family with a disorder of unknown inheritance. Note that individual 11 is known to have no affected alleles. Superscript a indicates the affected allele for sex-linked traits. (image attached) What are the possible genotypes of individual 1? XAXA aa Aa AA XAXa XaXaIn this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below. Key Ø Female: affected Female: unaffected || IV V 5600 orize 077808 15 10 9 10 CHO વ Male: affected Male: unaffected Deceased Disease status not given Dizygotic twins Monozygotic twins Fig. 1 Disease pedigree. Five generations I, II, III, IV, V are shown. Females are represented by circles, males by squares, dizygotic (non-identical) twins by diagonal lines originating from the same point, Monozygotic (identical) twins by diagonal lines originating from the same point and joined symbols and deceased by a diagonal line through the symbol. Filled symbols indicate that the individual displays the disease phenotype. Unfilled symbols indicate that the individual does not display the disease phenotype. Carriers of the disease are not indicated. Information on disease status is not known for generation I and is omitted for the individuals represented by a symbol with an asterisk.…
- Refer to Pedigree #1 Consider the children of individuals 1 and 2. Explain why one of the children is not affected even though the rest of the family is affected.The pedigree below shows a family with a history of an autosomal recessive genetic disease with one individual's genotype indicated (G denotes the normal allele and g denotes the disease-causing allele). * O 0 O 1/8 1/4 O 1/16 Individual 1's father is known to be heterozygous (*) and his mother is known to be homozygous dominant. Other individuals in the pedigree may be carriers, but are not marked. The question mark (?) indicates that you do not yet know anything about this individual's phenotype with regard to the disease. Part 1 What is the probability that individuals 1 and 2 will have a child (5) who is a male with the disease (the child is unborn and the sex is not yet known)? O 1/4 1 O 1/6 5 1/8 2 01/12 gg 3 Part 2 What is the probability that the daughter (female)(6) that individual 3 and 4 just had will have the disease? 6The following pedigree shows a family in which an inherited condition is apparent. The muscle biopsy from the one of the affected persons shows ragged red fibers and parking lot inclusions on microscopy. What is the most likely mode of inheritance for this condition? Answers A - E A Autosomal Dominant B Autosomal Recessive C Mitochondrial D X-linked Dominant E X-linked Recessive O O TO 0 ☐ Q
- Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele. Assume complete penetrance. I II III 3 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Based strictly on the characteristic patterns of inheritance that define the four different options in (a), give a definitive motivation for the most likely mode of inhertance.I II III II-1 11-2 Aa 1-1 11-3 Aa 1-2 II-4 III-1 Example: Given the pedigree above, what is the probability that the granddaughter (III-1) will be heterozygous? In order to determine the probability that III-1 is heterozygous, we need to determine the probability of the possible genotypes for her mother (II-2). Because the grandparents are both heterozygous, we would expect the following genotypic ratios in their offspring: ¼ AA, ½ Aa, and 14 aa. However, we have to use all possible information, and the circle representing III-1 is not shaded in, so she cannot be aa. Therefore, we eliminate the probability that II-2 is aa, and the final probability for II-2 is 1/3 AA and 2/3 Aa. We assume II-1 is AA because he is marrying into the family and we assume everyone marrying into a family is homozygous wild-type, unless proven otherwise. If II-2 is AA, and we assume II-1 is AA, then there is no chance that their daughter (III-1) is Aa If II-2 is Aa, and we assume II-1 is AA, then there is a…
- O Huntington's Disease is a rare neurodegenerative disorder caused by a defective gene. A pedigree is shown below with a family that is affected. Describe the pattern of inheritance that Huntington's Disease is following. Justify your answer with reference to the diagram. Use proper notation (II-3, etc.) when referring to individuals. II 2 3 6 8 II 1 2 3 4 5 7.Below is a pedigree of a family with a rare genetic disorder. I. IV. a. What is the mode of inheritance for this rare disorder and what is the genotype of I.1 and 1.2? b. Write the genotypes for the following individuals (if the genotype is unknown write all possible genotypes): i.) III.2 - ii) III.3 -Please consider the pedigree below. There are no cases of false paternity. I B II A 2 3 III AB (A IV в 1 a. Which individual/s definitely has/have Bombay phenotype in the descendants of I-1 and I-2? b. What are the genotypes of individuals II-2 and III-2 at the ABO and H loci?