c) How many patients would be required to detect the difference in proportions observed in the currentstudy with 80% power. A new investigation will be enrolling subjects to demonstrate the efficacy ofthe drug in individuals with high cholesterol at an early age. A two-sided test is planned at a = 0.05 .438. The following data were collected in a clinical trial to compare a new drug to a placebo for its effectivenessin lowering total serum cholesterol.94.4=sTotal Sample(n3150)194.15 (23.2)New DrugPlacebo(n=75)182.0 (24.5)(n=75)206.3 (21.8)Mean (SD) Total Serum Cholesterol78.0%65.0%71.5%% Patients with Total Cholesterol < 200(-26.72,-11.88)a) Generate the 95% confidence interval for the difference in mean total cholesterol levels betweentreatmentsb) Generate a 95% confidence interval for the difference in proportions of all patients with totalcholesterol < 200.

n1 = 75n2 = 75 x1 = 182x2 = 206.3 s1 = 24.5s2 = 21.8 The 95% CI is given byp1 =0.78p2 = 0.65 n1 = 75n2 = 75 The 95% CI is given by

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Statistics

-26.72,-11.88) a) Generate the 95% confidence interval for the difference in mean total cholesterol levels between treatments b) Generate a 95% confidence interval for the difference in proportions of all patients with total cholesterol < 200.

-26.72,-11.88) a) Generate the 95% confidence interval for the difference in mean total cholesterol levels between treatments b) Generate a 95% confidence interval for the difference in proportions of all patients with total cholesterol < 200.

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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Question

c) How many patients would be required to detect the difference in proportions observed in the current
study with 80% power. A new investigation will be enrolling subjects to demonstrate the efficacy of
the drug in individuals with high cholesterol at an early age. A two-sided test is planned at a = 0.05

.43
8. The following data were collected in a clinical trial to compare a new drug to a placebo for its effectiveness
in lowering total serum cholesterol.
94.4=s
Total Sample
(n3150)
194.15 (23.2)
New Drug
Placebo
(n=75)
182.0 (24.5)
(n=75)
206.3 (21.8)
Mean (SD) Total Serum Cholesterol
78.0%
65.0%
71.5%
% Patients with Total Cholesterol < 200
(-26.72,-11.88)
a) Generate the 95% confidence interval for the difference in mean total cholesterol levels between
treatments
b) Generate a 95% confidence interval for the difference in proportions of all patients with total
cholesterol < 200.

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