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- 15. Denaturation of ß-lactoglobulin is strongly related so many funcitonal proportes of dairy products such us (a) Deterioration of yoghurt texture and milk powder solubility dur (b) Improved yoghurt texture and milk powder solubility (e) Texture of yoghurt is improved and the solubility of milk powder is decreased (d) Deterioration of yoghurt texture and milk powder solubility improved 16. Types of continuous direct heating system, depending on the method used for mixing the product with steam: (a) Injection, higher in pressure steam than the product injected into the product stream through a nozzle and condenses, and infusion, where, the product is sprayed into the top of the vessel, steam condenses on the product while it falls. (b) Injection, higher in pressure steam than the product injected into the product stream through a vessel and condenses, and infusion, where, the product is sprayed into the top of the nozzle and the steam condenses on. (c) Injection, lower pressure steam…27. In the context of 6-mercaptopurine (6-MP) therapy for leukemia, which statement about thiopurine methyltransferase (TPMT) levels is correct? A) High TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse reactions. B) Low TPMT levels are associated with increased sensitivity to 6-MP and higher risk of adverse reactions C) High TPMT levels result in reduced metabolism of 6-MP, leading to decreased therapeutic efficacy D) Low TPMT levels result in increased metabolism of 6-MP, leading to excessive drug accumulation and toxicity.5. (a) Hexokinase IV is known as glucokinase (GCK) and is a central metabolic enzyme that participates in glucose homeostatic maintenance by governing the rates of glucose catabolism in pan- creatic B-cells and glycogen storage in hepatocytes (liver cells). In contrast to the regulatory mecha- nisms of hexokinase I or Il in other tissues, GCK is regulated by binding to the Glucokinase Regulatory Protein (GRP) located in the cell nucleus. When glucose in hepatocytes is low, GCK is sequestered in the nucleus by binding to the GRP. High glucose, for instance, after ingestion of a meal, disrupts the GRP-GCK complex, allowing the GCK to diffuse into the cytoplasm to convert glucose into glucose-6- phosphate. Contrast the properties of hexokinases I and IV with respect to oligomeric structure, mech- anism of regulation of their activity, KM value, and dependence of catalytic activity on cellular location. Hexokinase I is found in, for instance, muscle tissue. Property subunit structutre…
- 5. (a) Hexokinase IV is known as glucokinase (GCK) and is a central metabolic enzyme that participates in glucose homeostatic maintenance by governing the rates of glucose catabolism in pan- creatic B-cells and glycogen storage in hepatocytes (liver cells). In contrast to the regulatory mecha- nisms of hexokinase I or Il in other tissues, GCk is regulated by binding to the Glucokinase Regulatory Protein (GRP) located in the cell nucleus. When glucose in hepatocytes is low, GCK is sequestered in the nucleus by binding to the GRP. High glucose, for instance, after ingestion of a meal, disrupts the GRP-GCK complex, allowing the GCK to diffuse into the cytoplasm to convert glucose into glucose-6- phosphate. Contrast the properties of hexokinases I and IV with respect to oligomeric structure, mech- anism of regulation of their activity, KM value, and dependence of catalytic activity on cellular location. Hexokinase l is found in, for instance, muscle tissue. Property subunit structutre…Lactic acidosis is a potential adverse side effect most commonly seen with which of these agents? Select one: a. Metformin (Glucophage) b. Glipizide (Glucotrel c. Repaglinide (Prandin) d. Miglitol (Glyset).Synthesis of prostaglandinsis is inhibited by (A)Aspirin (B)Arsenic (C)Fluoride (D)Cyanide
- 2. Peter is diabetic. So the molecular biologist cloned a DNA sequence in Peter's body cells that will synthesize insulin hormone. 5' AGCTAGACGCATCCTAATG-GCC-ACT-GAA-TCC-TGAATGGACGA 3' a) What will be the RNA of this insulin gene Sequence? b) How many amino acids will be translated from this mRNA? c) Give the amino-acid sequence of insulin.60. During an experiment, an inbred mouse strain is developed that has a homozygous mutation for the gene encoding the J chain. Immunoglobulins produced by these mice are most likely to have alterations in which of the following biologic properties? 00 A) Ability to pass across the placenta B) Attachment to Fc receptors on eosinophils C) Neutralization of toxins D) Opsonization of encapsulated bacteria E) Secretion across mucosal epithelial cellsem 92 of 145 Z 92. During an experiment, a researcher inactivates the fibroblast growth factor receptor gene expressed on grandiosa celih Which of the folog A) Absence of androgen production B) Formation of tumors from thecal cells C) Inhibition of formation of the follicular antrum D) Premature ovulation E) Transformation of thecal cells into granulosa cells